Electron beam lithography designed silver nano-disks used as label free nano-biosensors based on localized surface plasmon resonance

Optics Express
Neval A CinelEkmel Özbay

Abstract

We present a label-free, optical nano-biosensor based on the Localized Surface Plasmon Resonance (LSPR) that is observed at the metal-dielectric interface of silver nano-disk arrays located periodically on a sapphire substrate by Electron-Beam Lithography (EBL). The nano-disk array was designed by finite-difference and time-domain (FDTD) algorithm-based simulations. Refractive index sensitivity was calculated experimentally as 221-354 nm/RIU for different sized arrays. The sensing mechanism was first tested with a biotin-avidin pair, and then a preliminary trial for sensing heat-killed Escherichia coli (E. coli) O157:H7 bacteria was done. Although the study is at an early stage, the results indicate that such a plasmonic structure can be applied to bio-sensing applications and then extended to the detection of specific bacteria species as a fast and low cost alternative.

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Citations

Mar 16, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Chiara Valsecchi, Alexandre G Brolo
Oct 27, 2012·Analytical Chemistry·Limei TianSrikanth Singamaneni
Apr 11, 2017·ACS Applied Materials & Interfaces·Serkan ButunKoray Aydin
Mar 10, 2016·Physical Chemistry Chemical Physics : PCCP·Renjie HouFrançois Lagugné-Labarthet
Feb 13, 2018·Expert Review of Molecular Diagnostics·Andrea CsákiWolfgang Fritzsche
Nov 2, 2019·Analytical Methods : Advancing Methods and Applications·Jiayun HuPaul W Bohn
Jan 16, 2019·Applied Optics·Xiaoyu FengZhongyue Zhang
Aug 25, 2020·Advanced Theory and Simulations·Chandreyee Manas DasKen-Tye Yong

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