PMID: 11345357May 10, 2001Paper

Electron beam tomography and National Cholesterol Education Program guidelines in asymptomatic women

Journal of the American College of Cardiology
H S Hecht, H R Superko

Abstract

This investigation was designed to determine the relationship between National Cholesterol Education Program (NCEP) ATP-II lipid guidelines and subclinical atherosclerosis, defined by electron beam tomography (EBT) calcified coronary plaque, in asymptomatic women. NCEP guidelines are used to identify women at increased risk for coronary artery disease (CAD) on the basis of low density lipoprotein cholesterol (LDLC) and high density lipoprotein cholesterol (HDLC) values. The relationship of the guidelines to subclinical atherosclerosis is unknown. A total of 304 asymptomatic women underwent lipid and EBT evaluation and were classified as: 1) NCEP higher risk, with LDLC > or =130 mg/dl and/or HDLC <35 mg/dl, or lower risk with LDLC <130 mg/dl and HDLC > or =35 mg/dl; and 2) EBT+ if any calcified plaque was noted or EBT- if there was no calcified plaque. Forty-two percent of patients were EBT+, with a mean score of 227 and percentile of 73%; 58% were EBT-. Women who were EBT+ had significantly higher total cholesterol, LDLC and triglycerides than EBT- women, but only with ages < or =55 years; women >55 years demonstrated no differences. NCEP higher risk women made up 53.5% of the EBT+ and 37.7% of the EBT- groups; NCEP lower risk ...Continue Reading

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Citations

Jan 18, 2006·Zeitschrift für Kardiologie·S Silber, B M Richartz
Aug 7, 2001·Current Atherosclerosis Reports·H S Hecht
Sep 25, 2003·Progress in Cardiovascular Diseases·Harvey S Hecht
May 10, 2001·Journal of the American College of Cardiology·S M Grundy
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