Electron-capture gas chromatographic analysis of beta-phenylethylamine in tissues and body fluids using pentafluorobenzenesulfonyl chloride for derivatization

Journal of Chromatography
G B BakerR T Coutts


A gas chromatographic procedure is described for the analysis of beta-phenylethylamine (PEA) in tissues and body fluids. The method involves the use of pentafluorobenzenesulfonyl chloride for extraction and derivatization of PEA. This is followed by separation and analysis of the derivatized amine on a gas chromatograph equipped with a fused-silica capillary column and an electron-capture detector. The procedure is rapid, provides a stable and sensitive derivative, and has been applied to analysis of PEA in brain, heart, kidney, liver, lung, spleen and blood from the rat and urine from human subjects.


Sep 1, 1987·Cellular and Molecular Neurobiology·R T CouttsT W Hall
Sep 1, 1993·Neurochemical Research·G B BakerV K Yeragani
Jan 1, 1991·Biological Psychiatry·G B BakerR T Coutts
Apr 1, 1991·Journal of Pharmacological Methods·M L OwenW G Dewhurst
Apr 21, 1995·Journal of Chromatography. B, Biomedical Applications·T A McAllisterJ R Thompson
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T KumazawaH Hattori
Nov 21, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·L J UrichukG B Baker
Jun 8, 2001·Journal of Pharmacological and Toxicological Methods·M SalsaliG B Baker
May 9, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhao-Qian LiuHong-Hao Zhou
Jan 1, 1993·Journal of Pharmaceutical Sciences·P R PaetschA J Greenshaw

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