Electron competition process in respiratory chain: regulatory mechanisms and physiological functions

Biochimica Et Biophysica Acta
Michel RigouletAnne Devin

Abstract

In mitochondria isolated from the yeast Saccharomyces cerevisiae, under non-phosphorylating conditions, we have previously shown that there is a right of way for electrons coming from the external NADH dehydrogenase, Nde1p. In this work, we show that the electron competition process is identical under more physiological conditions i.e. oxidative phosphorylation. Such a competition generates a priority for cytosolic NADH reoxidation. Furthermore, this electron competition process is associated with an energy wastage (the "active leak") that allows an increase in redox equivalent oxidation when the redox pressure increases. When this redox pressure is decreased, i.e. under phosphorylating conditions, most of this energy wastage is alleviated. By studying mutant strains affected either in respiratory chain supramolecular organization or in electron competition activity, we show that the respiratory chain supramolecular organization is not responsible for the electron competition processes. Moreover, we show two distinct relationships between the respiratory rate and the quinone redox state that seem to indicate two quinone pools that are involved in the electron right of way. Indeed, the more reduced pool would be associated to th...Continue Reading

References

Sep 17, 1968·Biochimica Et Biophysica Acta·E A Liberman, V P Topaly
Jan 1, 1966·Acta Chemica Scandinavica·K Nordström
May 27, 1983·Biochimica Et Biophysica Acta·D PietrobonG F Azzone
Apr 1, 1983·Journal of General Microbiology·P M BruinenbergW A Scheffers
Apr 25, 2000·The EMBO Journal·H Schägger, K Pfeiffer
Jan 19, 2002·IUBMB Life·H Schägger
Oct 17, 2003·The Journal of Biological Chemistry·Kathy PfeifferHermann Schägger
Dec 1, 1967·The Biochemical Journal·P Mitchell, J Moyle
Jun 20, 2006·Biochimica Et Biophysica Acta·Ilka WittigHermann Schägger
Feb 5, 2008·Molecular & Cellular Proteomics : MCP·Ilka WittigHermann Schägger
Nov 10, 2009·Biochimica Et Biophysica Acta·Arnaud MourierMichel Rigoulet

❮ Previous
Next ❯

Citations

Oct 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martin TrouillardFabrice Rappaport
Jul 15, 2015·Biochimica Et Biophysica Acta·Nicole AvéretMichel Rigoulet
Mar 25, 2014·Biochimie·Alfredo Cabrera-OreficeSalvador Uribe-Carvajal
Dec 4, 2014·Cell Metabolism·Arnaud MourierDusanka Milenkovic
Aug 13, 2013·Biochimica Et Biophysica Acta·Alfredo Cabrera-OreficeSalvador Uribe-Carvajal
Jan 9, 2014·Human Molecular Genetics·Arnaud MourierNils-Göran Larsson
Jul 28, 2020·Biochimica Et Biophysica Acta. Bioenergetics·M RigouletA Devin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.