Electron-Electron Dipolar Interaction Poses a Challenge to the Radical Pair Mechanism of Magnetoreception

The Journal of Physical Chemistry Letters
Nathan S Babcock, Daniel R Kattnig

Abstract

A visual magnetic sense in migratory birds has been hypothesized to rely on a radical pair reaction in the protein cryptochrome. In this model, magnetic sensitivity originates from coherent spin dynamics, as the radicals couple to magnetic nuclei via hyperfine interactions. Prior studies have often neglected the electron-electron dipolar (EED) coupling from this hypothesis. We show that EED interactions suppress the anisotropic response to the geomagnetic field by the radical pair mechanism in cryptochrome and that this attenuation is unlikely to be mitigated by mutual cancellation of the EED and electronic exchange coupling, as previously suggested. We then demonstrate that this limitation may be overcome by extending the conventional model to include a third, nonreacting radical. We predict that hyperfine effects could work in concert with three-radical dipolar interactions to tailor a superior magnetic response, thereby providing a new principle for magnetosensitivity with applications for sensing, navigation, and the assessment of biological magnetic field effects.

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Citations

Jan 28, 2021·The Journal of Chemical Physics·Siu Ying WongDaniel R Kattnig
Nov 16, 2020·Bioelectromagnetics·Lucián ZastkoIgor Belyaev
Mar 10, 2021·The Journal of Chemical Physics·Robert H KeensDaniel R Kattnig
Jun 8, 2021·Frontiers in Physiology·Roswitha WiltschkoWolfgang Wiltschko
May 17, 2021·Protein Science : a Publication of the Protein Society·Nischal KarkiBrian D Zoltowski
Jul 10, 2021·The Journal of Chemical Physics·Daniel R Kattnig
Nov 11, 2021·Journal of the Royal Society, Interface·Siu Ying WongP J Hore

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