PMID: 7013904Apr 6, 1981Paper

Electron immunocytochemistry in vasoactive intestinal peptide (VIP) in the rat brain

Brain Research
G PelletierJ M Polak

Abstract

In order to clearly identify the cellular elements as well as the organelles containing vasoactive intestinal peptide (VIP), an immunocytochemical localization of this peptide was performed in the rat brain. Ultrastructural localization studies involving use of both pre- and post-embedding staining techniques clearly demonstrated that VIP immunoreactivity was associated with dendrites and axonal processes. In dendrites, the labeling was rather diffuse throughout the cytoplasm whereas in terminals it was observed in large dense core vesicles and not within the small clear vesicles. About 50% of positive endings were observed forming typical synaptic contact. These results support the hypothesis that VIP can act as a neurotransmitter.

References

Nov 1, 1978·Gut·S J Mitchell, S R Bloom
Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·L I LarssonJ R Rehfeld

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Citations

May 13, 1999·The Journal of Comparative Neurology·C W MorganD E Scott
May 1, 1990·Journal of Electron Microscopy Technique·B E Maley
Jan 1, 1989·Molecular Neurobiology·I Gozes, D E Brenneman
Jan 1, 1991·Progress in Neurobiology·E S Vizi, E Lábos
Aug 1, 1982·Molecular and Cellular Endocrinology·G RosselinW Rostène
Dec 30, 1983·Neuroscience Letters·Y Y Chen, G Pelletier
Mar 1, 1984·Brain Research Bulletin·H L Obata-TsutoY Ibata
Feb 1, 1996·Micron : the International Research and Review Journal for Microscopy·G K Zupanc
Mar 1, 2012·Neuropharmacology·Jennifer A Parker, Stephen R Bloom
Sep 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tatiana YakovlevaGeorgy Bakalkin
Jun 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M el-SalhyL Grimelius
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy

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