PMID: 701360Sep 1, 1978Paper

Electron microscope localization of acetylcholinesterase and butyrylcholinesterase in the superior cervical ganglion of the cat. I. Normal ganglion

The Journal of Cell Biology
R Davis, G B Koelle

Abstract

The distributions of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in the superior cervical ganglion (SCG) of the cat were determined by electron microscopy (EM) with the bis-(thioacetoxy)aurate (I), or Au(TA)2, method. Before the infusion of fixative, one of the enzymes was selectively, irreversibly inactivated in vivo, as confirmed by light microscope (LM) examination of sections of the stellate ganglion stained by the more specific copper thiocholine method. Physostigmine-treated controls, for inhibition of AChE or BuChE, were stained concomitantly with tissue for enzyme localization by the Au(TA)2 method for EM examination in each experiment. It was concluded that most of the AChE of the cat SCG is present in the plasma membranes of the preganglionic axons and their terminals, and in the dendritic and perikaryonal plasma membranes of the postsynaptic ganglion cells. BuChE is confined largely to the postsynaptic neuronal plasma membranes. Reasons for the discrepancies between the localizations found by the present direct EM observations and those deduced earlier from LM comparisons of normal and denervated SCG are discussed. It is proposed that a trophic factor released by the preganglionic terminals is proba...Continue Reading

References

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Citations

Feb 1, 1991·Cellular and Molecular Neurobiology·P G Layer
Mar 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S B BackmanC Polosa
Nov 1, 1990·Brain Research. Developmental Brain Research·C S Heck, P A McKinley
Jan 9, 1998·Progress in Neurobiology·L DescarriesM Steriade
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G B KoelleG A Ruch
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·E Uchida, G B Koelle
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G B KoelleG Boulla
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G B KoelleM S Han
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R L RotundoW R Randall
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G B KoelleR Caccese
Dec 30, 1987·European Journal of Biochemistry·I Silman, A H Futerman
Mar 1, 1984·Journal of Neurochemistry·E Meisami
Jun 1, 1986·Bioscience Reports·R E Catalan, F Hernandez
Jan 1, 1990·Annals of the New York Academy of Sciences·G B Koelle

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