PMID: 14405103Jun 1, 1960Paper

Electron microscope study of the lathyritic rat aorta

The Journal of Biophysical and Biochemical Cytology
M K KEECH

Abstract

Six weanling rats were fed a diet containing 0.4 per cent BAPN fumarate and sacrificed after 5 to 33 days on the diet. The ascending aortae were fixed with OsO(4), embedded in methacrylate and araldite, sectioned, stained with lead hydroxide, and examined with the electron microscope. The descending thoracic aortae were examined by light microscopy. Compared with pair-fed controls, the experimentals showed definite changes which became more marked as the disease progressed. The wall became thicker with wider interlaminar spaces, radial orientation of the smooth muscle cells, progressive loss of desmosomes, and progressive increase in a dense, finely stippled material that coated the edges of the elastic laminae and extended outwards between the muscle cells and separated the ends of these cells from the laminae. This stippled material occurred at the same sites as the increase in PAS-positive and azan-positive material seen with the light microscope. There was an increase in subendothelial and interlaminar collagen, and electron microscopy clearly showed that the cells were smooth muscle and not fibroblasts. The possible bearing of the morphological changes on the formation of aortic aneurysms is discussed.

References

Oct 29, 1954·Science·T E BACHHUBER, J J LALICH
Oct 1, 1954·Archives of Biochemistry and Biophysics·G F McKAYF M STRONG
Nov 25, 1957·The Journal of Biophysical and Biochemical Cytology·R CAESARH RUSKA
Jun 1, 1958·Journal of Dental Research·A F GARDNERJ P WEINMANN
Jun 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·T E BACHHUBERF M STRONG
Jun 1, 1960·The Journal of Biophysical and Biochemical Cytology·M K KEECH

❮ Previous
Next ❯

Citations

Jan 1, 1975·Virchows Archiv. A, Pathological Anatomy and Histology·G Genzeli, M L Cucchi
Jan 6, 2016·Life Sciences·Maryam RameshradRohollah Fadaei Fouladi
Nov 2, 2015·Biochimica Et Biophysica Acta·Liangqiang ZouGuoheng Xu
Aug 1, 1976·Experimental and Molecular Pathology·B W OakesP E Campbell
Aug 1, 1962·Experimental and Molecular Pathology·C F SIMPSONJ H SAUTTER
Aug 1, 1981·Experimental and Molecular Pathology·I Pasquali-RonchettiD Volpin
Aug 1, 1966·Experimental and Molecular Pathology·J U BalisP E Conen
Mar 1, 1961·Journal of Ultrastructure Research·H E KARRER
Jun 1, 1966·Journal of Ultrastructure Research·W E Stehbens
Mar 1, 1983·The Journal of Experimental Zoology·S M Newman, J N Dumont
Oct 1, 1967·Arthritis and Rheumatism·A L Weaver
Aug 1, 1964·Journal of the American Geriatrics Society·H BICKLEY

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.