PMID: 7940016May 1, 1994Paper

Electron microscopic analysis of in vitro replication products of ors 8, a mammalian origin enriched sequence

Somatic Cell and Molecular Genetics
C E PearsonM Zannis-Hadjopoulos


Electron microscopy was used to map the initiation site of ors 8 DNA replication in vitro in a system that is capable of initiating and supporting one round of semiconservative replication of cloned mammalian DNA origin-enriched sequences (ors). Using unique restriction sites in ors 8 plasmid DNA, we have mapped the replication bubble within the monkey DNA sequence. In addition to site-specific initiation within the ors, the results also indicate bidirectional replication.


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Mar 1, 1991·Molecular and Cellular Biology·P J Krysan, M P Calos
Apr 25, 1990·Nucleic Acids Research·J P VaughnJ L Hamlin
Jul 1, 1985·Molecular and Cellular Biology·M Zannis-HadjopoulosR G Martin
May 23, 1986·Science·S A Wasserman, N R Cozzarelli
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L Frappier, M Zannis-Hadjopoulos
Nov 15, 1984·Journal of Molecular Biology·M Zannis-HadjopoulosR G Martin
Feb 4, 1994·Science·W C Burhans, J A Huberman
Oct 1, 1993·Molecular and Cellular Biology·V J Virta-PearlmanA C Chinault
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K AriizumiP W Tucker

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