Electron microscopic features of experimental choroidal neovascularization

American Journal of Ophthalmology
D B Archer, T A Gardiner

Abstract

We produced choroidal neovascularization in the rhesus monkey by diminishing the blood supply to the inner retina and producing defects in Bruch's membrane by photocoagulation. The neovascular fronds which developed either infiltrated the subretinal space or proliferated through necrotic and gliotic retina into the vitreous cavity. Sequential electron microscopic sections of neovascular fronds in the subretinal space demonstrated that the advancing capillary sprouts were composed of primitive endothelial tubes surrounded by pericytes and enmeshed in a loose basement-membrane-like substance. More mature capillaris and displayed endothelial fenestrations and endothelial-pericyte membranous contacts. Large neovascular fronds developed major feeding vessels that closely resembled normal small choroidal arteries and veins. Retinal pigment epithelial cells in various guises were in constant association with proliferating neovascular networks.

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Citations

Aug 15, 1985·American Journal of Ophthalmology·J V Jester, R E Smith
Dec 14, 1999·Survey of Ophthalmology·J I Lim
Feb 1, 1983·International Ophthalmology·D B Archer, T A Gardiner
Apr 1, 1996·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Z I CurrieJ F Talbot
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Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P L PenfoldF A Billson
Jan 1, 1989·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E van der ZypenS Kwasniewska
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Feb 3, 2021·International Journal of Molecular Sciences·Yue RuanAdrian Gericke
Mar 23, 2021·Current Tissue Microenvironment Reports·Laura Beth PayneJohn C Chappell

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