Electron-microscopic findings after transmyocardial laser revascularization in an acute ischemic pig model

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
M MisfeldH H Sievers

Abstract

The clinical benefit in terms of angina reduction after transmyocardial laser revascularization (TMLR) in patients with diffuse coronary artery disease who are not candidates for conventional procedures has been proved. The exact mechanisms of TMLR however, are still unknown. The aim of this study was to investigate the cellular changes in relation to intramyocardial partial oxygen pressure (ptiO2) after TMLR in a model of acute ischemia in pigs by electron microscopical methods (TEM). Seven pigs were included in this study (five animals with acute myocardial ischemia and additional TMLR and two animals with acute myocardial ischemia and without TMLR for control). Acute ischemia was induced by ligation of diagonal branches of the left anterior descending artery (LAD). Intramyocardial partial oxygen pressure was measured before induction of ischemia and thereafter continuously for up to 6 h in all animals. Biopsies of all animals were taken before induction of ischemia and thereafter at 30 min, 3 and 6 h. Analysis of the myocardial ultrastructure was focused on mitochondria, cell nucleus, T-tubules and myofibrils. Ultrastructural changes were seen in all animals. At 6 h after induction of ischemia, mitochondria showed a destruct...Continue Reading

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Citations

Jun 16, 2001·Japanese Circulation Journal·S YamamotoS Sano
Mar 31, 2000·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M M PucA J DelRossi

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