Electron-microscopic investigation of muscle mitochondria in chronic fatigue syndrome

Neuropsychobiology
A V Plioplys, S Plioplys

Abstract

Patients with chronic fatigue syndrome (CFS) suffer from disabling physical and mental fatigue. Abnormalities in mitochondrial function can lead to fatigue and weakness. Ultrastructural mitochondrial abnormalities have been reported to be present in CFS patients. We obtained percutaneous needle muscle biopsies from 15 CFS patients and 15 age- and sex-matched controls. We investigated previously reported ultrastructural abnormalites in CFS: subsarcolemmal mitochondrial aggregates, intermyofibrillar mitochondrial aggregates, mitochondrial circumference, area, pleomorphism and the presence of compartmentalization of the inner mitochondrial membrane. All of the steps of tissue processing, electron microscopy and data abstracting and analysis were performed in a totally blinded fashion. All of our data were rigorously quantified. We found no difference in any of these studied parameters between CFS patients and controls. Although there is no ultrastructural mitochondrial abnormality in CFS patients, other lines of evidence suggest the presence of a possible functional mitochondrial abnormality.

Citations

Oct 29, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·J StewartJ Munoz
Apr 1, 2002·Journal of the American Aging Association·Carlo Bertoni-FreddariJacopo Vecchiet
Sep 19, 1998·Medicine and Science in Sports and Exercise·D G RowbottomA R Morton
Jun 13, 2012·Case Reports in Surgery·Nicole Lightfoot, Mehrdad Nikfarjam
Jan 23, 2016·Journal of Translational Medicine·Paul Billing-RossMaureen R Hanson
Aug 26, 2014·BBA Clinical·Kristin FillerLeorey N Saligan
Mar 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Pou Kuan LeongKam Ming Ko
Feb 16, 2008·Journal of Muscle Research and Cell Motility·Stefania FulleGiorgio Fanò
Feb 28, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·E G Klaver-KrolM J Zwarts

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