PMID: 5347694Nov 1, 1969Paper

Electron microscopic studies on streptococci. I. M antigen

The Journal of Experimental Medicine
J SwansonE C Gotschlich

Abstract

The presence of M antigens on group A streptococci is associated with hairlike fimbriae that cover the surface of the streptococcal cell wall and are demonstrable by electron microscopy. These fimbriae also may be associated with R antigen. Like M protein, the surface fimbriae are destroyed by trypsin treatment and reappear when "trypsinized" streptococci are reincubated in fresh, trypsin-free broth. Ferritin-conjugated, type-specific antibodies localize on homologous M+ cells in a pattern suggestive of several M antigenic sites along the length of individual surface fimbria. The M-associated fimbriae remain on the residual cell wall after removal of the bulk of group-specific polysaccharide through nitrous acid extraction. This suggests attachment of the fimbriae to the mucopeptide and minor polysaccharide components remaining in the nitrous acid-extracted wall. The pattern of localization of ferritin-conjugated antibodies on homologous streptococci before and after trypsin exposure and upon reincubation of the trypsinized cells in fresh medium suggests the following hypothesis: M antigen is secreted by the cell, is partially excreted through the otherwise intact cell wall, and is bound by the wall so that M protein occupies a...Continue Reading

References

Mar 2, 1962·Science·R M COLE, J J HAHN
Mar 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·E N FOX
Nov 1, 1963·The Journal of Experimental Medicine·J J HAHN, R M COLE
May 1, 1965·The Journal of Cell Biology·J H VENABLE, R COGGESHALL
Oct 31, 1946·The Journal of Experimental Medicine·R C Lancefield, V P Dole

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Citations

Sep 1, 1988·European Journal of Epidemiology·B N Manjula
Feb 1, 1986·Molecular Immunology·D G PritchardJ R McGhee
Aug 11, 1977·The New England Journal of Medicine·G Peter, A L Smith
Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Assaf Raz, Vincent A Fischetti
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B HoseinV A Fischetti
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G N PhillipsV A Fischetti
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B N ManjulaV A Fischetti
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J R ScottV A Fischetti
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M G Caparon, J R Scott
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W Kraus, E H Beachey
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K F JonesV A Fischetti
Dec 27, 2011·Molecular & Cellular Proteomics : MCP·Cesira L GaleottiRenata Grifantini
Aug 1, 1971·The Journal of Experimental Medicine·E H Beachey, G H Stollerman
Jul 1, 1973·The Journal of Experimental Medicine·J Swanson, E C Gotschlich
Apr 1, 1976·The Journal of Experimental Medicine·E H Beachey, I Ofek
Nov 1, 1980·The Journal of Experimental Medicine·J G Spanier, P P Cleary
Mar 1, 1985·The Journal of Experimental Medicine·K F JonesV A Fischetti
Jun 1, 1985·The Journal of Experimental Medicine·V A FischettiJ R Scott
Oct 1, 1986·The Journal of Experimental Medicine·V A FischettiJ R Scott
Feb 1, 1989·The Journal of Experimental Medicine·W KrausE H Beachey
Nov 1, 1989·The Journal of Experimental Medicine·M S BlakeK P Klugman
Mar 1, 1983·Microbiological Reviews·S K Unny, B L Middlebrooks
Nov 1, 1991·The British Journal of Dermatology·J McFaddenL Fry
Aug 1, 1995·Scandinavian Journal of Immunology·H HociniJ P Bouvet
May 10, 1974·Annals of the New York Academy of Sciences·G D ShockmanM L Higgins
Jul 1, 1978·Antimicrobial Agents and Chemotherapy·J R Tagg, L W Wannamaker
Jul 25, 2000·Clinical Microbiology Reviews·M W Cunningham
May 20, 2003·Journal of Bacteriology·Daniel NelsonVincent A Fischetti

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