PMID: 42212Oct 1, 1979

Electron microscopic studies on the small intestine of rats after mechanical intestinal obstruction

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
M YamamotoW Oehlert


The morphologic changes of the small intestine after the mechanical obstruction were studied by light and electron microscopy. After the ligation of the upper small intestine, segments of jejunum, both proximal and distal to the site of obstruction, were removed at intervals varying from 45 min to 24 h. The essential changes were found in the epithelial cells of the tips of villi, and few morphologic differences were recognized between samples proximal and distal to the site of obstruction. The most remarkable changes in the mucosa were the pseudopodlike extension of the cytoplasm, vacuolar alteration of the villus epithelial cells, desquamation of these degenerated cells, and the dilatation of the epithelial intercellular spaces. A few epithelial cells showed hypertrophy of the smooth endoplasmic reticulum. In the submucosa, vascular stasis and edema were observed throughout the course. The mechanism of fluid loss into the intestinal lumen was discussed briefly.


Jan 1, 1980·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M YamamotoW Oehlert
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Aug 1, 1981·European Journal of Clinical Investigation·J B HeneghanB Winistörfer


Feb 1, 1976·Clinical Science and Molecular Medicine·V MirkovitchS Gomba
Dec 1, 1973·The Japanese Journal of Surgery·H KameiK Sugimoto
Jan 1, 1970·Annual Review of Physiology·T R Hendrix, T M Bayless
Oct 1, 1965·The British Journal of Surgery·R Shields
Dec 1, 1953·British Journal of Pharmacology and Chemotherapy·W FELDBERG, A N SMITH
May 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A J SPEECE

Related Concepts

Extracellular Space
Structure of Intestinal Gland
Electron Microscopy
Varicose Ulcer
Intestinal Obstruction
Intestines, Small
Endoplasmic Reticulum

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