Electron-microscopic study of sclerodermatous chronic graft-versus-host disease

International Journal of Dermatology
H TabataS Yamazaki

Abstract

Sclerodermatous chronic graft-versus-host disease (SC-GVHD) resembles systemic scleroderma (SSD) closely, both clinically and histologically. Our purpose was to try to define the morphologic differences of collagen fibers between SC-GVHD and SSD. Using electron microscopy, we compared the morphology of collagen fibers in a 15-year old girl with SC-GVHD with those of three patients with SSD. In SC-GVHD, sclerosis is located in the superficial dermis and collagen fibers of irregular diameter are seen in the subepidermal area. In SSD, sclerosis is seen in the lower dermis and subcutaneous fatty tissue, and collagen fibers of irregular diameter are located in the deep dermis. Some of the collagen fibers were degenerative in the superficial dermis in SC-GVHD. We observed low-density, round structures in cross sections of collagen fibers. The difference in initial location and morphologic appearance of collagen fibers may indicate a different pathogenesis in SC-GVHD compared to SSD.

References

Dec 1, 1977·Annals of Internal Medicine·T J LawleyA B Deisseroth
May 1, 1979·Arthritis and Rheumatism·Y KumagaiY Shiokawa
Jan 1, 1992·Journal of the American Academy of Dermatology·O ChosidowJ Revuz
Sep 1, 1991·Journal of the American Academy of Dermatology·R PrussickD N Sauder
Sep 1, 1983·Clinical and Experimental Dermatology·R A Graham-Brown, I Sarkany
Aug 1, 1980·The American Journal of Medicine·H M ShulmanE D Thomas
Jun 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·B PERNIS, F PARONETTO

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Citations

Feb 27, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·In-Sung ChoiSam-Gyu Lee
Mar 17, 2004·The American Journal of Dermatopathology·Cezary KowalewskiStefania Jablońska
Nov 30, 2005·The American Journal of Dermatopathology·Cezary KowalewskiStefania Jabłońska
Oct 4, 2005·Journal of the American Academy of Dermatology·Julie V SchafferJean L Bolognia
Jan 13, 2000·Pediatric Dermatology·P L Shannon, M J Ford
Oct 12, 1999·International Journal of Dermatology·S CórdobaA García-Díez
Jan 25, 2002·American Journal of Physical Medicine & Rehabilitation·Donald M CurrieNaynesh Kamani

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