PMID: 6963274Dec 1, 1982Paper

Electron microscopic study on the effects of vinblastine on young odontoblasts in rat incisor

Journal de biologie buccale
Y MiakeS Takuma

Abstract

Young Wistar male rats were injected intravenously with 2 mg/kg of vinblastine sulfate. After three, six, 12, 24 and 48 hours, the upper incisors were dissected out of the animals, and their young odontoblasts were observed in an electron microscope. Three to six hours after the injection, the regular polarity of the nuclei and the cytoplasmic organelles were dramatically changed following a decrease in the number of microtubules. Disturbance in protein synthesis was suggested at this stage by unusual shapes and the arrangement of the rough endoplasmic reticulum and loss of the polysomal arrangement of the ribosomes attached to the reticulum. After more than 12 hours, accumulation of secretion granules and the occurrence of bodies, containing a few strands of collagen-like fibrils, were frequently seen in various portions of the cells, indicating retarded export of the secretion substance. Occurrence of a number of unusually short fibrils in predentin was another prominent feature noticed in later stages. The fibrils were about 3000A long by 2000A or 600A wide, and many of the 2000A wide fibrils were characterized by a banded structure which resembled the previously reported SLS collagen. The 600A wide fibrils were usually band...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.