PMID: 6169285Jul 1, 1981Paper

Electron microscopy in the long-term follow-up of Whipple's disease. Effect of antibiotics

The American Journal of Surgical Pathology
R B DenholmI A More

Abstract

The electron-microscopic and light-microscopic findings on jejunal biopsies from a case of Whipple's disease are described. Seven biopsies were obtained over a 3-year period. Rapid clinical recovery was accompanied by the disappearance of interstitial and intracellular bacteria from the lamina propria. The pathognomonic PAS-positive material on light microscopy corresponding to the phagocytic vacuoles in the macrophages of the lamina propria decreased markedly in amount but persisted throughout the 3-year-period. The sequential changes in the jejunal mucosa and in particular those occurring in macrophages are described and their relation to pathogenesis is discussed.

Citations

Oct 4, 1984·The New England Journal of Medicine·N B RatliffD M Cosgrove
Nov 21, 2000·Postgraduate Medical Journal·R N Ratnaike
Nov 21, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alessandra LoiodiceDomenico Piscitelli
Jul 24, 2001·Ultrastructural Pathology·C E CominG Pasquinelli
Jan 1, 1985·Histopathology·C W AdamsB H Hicks

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