Electron paramagnetic resonance imaging of tumor pO₂

Radiation Research
Murali C KrishnaJames B Mitchell

Abstract

Electron paramagnetic resonance imaging (EPRI) can be used to noninvasively and quantitatively obtain three-dimensional maps of tumor pO₂. The paramagnetic tracer triarylmethyl (TAM), a substituted trityl radical moiety, is not toxic to animals and provides narrow isotropic spectra, which is ideal for in vivo EPR imaging experiments. From the oxygen-induced spectral broadening of TAM, pO₂ maps can be derived using EPRI. The instrumentation consists of an EPRI spectrometer and 7T magnetic resonance imaging (MRI) system both operating at a common radiofrequency of 300 MHz. Anatomic images obtained by MRI can be overlaid with pO₂ maps obtained from EPRI. With imaging times of less than 3 min, it was possible to monitor the dynamics of oxygen changes in tumor and distinguish chronically hypoxic regions from acutely hypoxic regions. In this article, the principles of pO₂ imaging with EPR and some relevant examples of tumor imaging are reviewed.

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D S WilliamsA P Koretsky
Mar 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R P MasonP P Antich
May 1, 1997·International Journal of Radiation Oncology, Biology, Physics·D M BrizelM W Dewhirst
Jul 9, 1998·Journal of Magnetic Resonance·J H Ardenkjaer-LarsenK Golman
Aug 13, 1999·The American Journal of Physiology·R D BraunM W Dewhirst
Dec 22, 1999·Biochemical Pharmacology·G L Semenza
Dec 21, 2000·Journal of the National Cancer Institute·T L ChenevertB D Ross
Feb 24, 2001·Cancer Metastasis Reviews·G L Semenza
May 18, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R D BraunM W Dewhirst
May 22, 2002·Academic Radiology·Klaes GolmanJohan Overweg
Dec 24, 2002·Cancer Biology & Therapy·J Martin Brown
Apr 23, 2003·Anesthesia and Analgesia·Huagang HouHarold M Swartz
Aug 10, 1956·Science·O WARBURG
Jan 31, 2004·International Journal of Radiation Oncology, Biology, Physics·Kjetil G BrurbergEinar K Rofstad
Aug 12, 2004·Physiology·Gregg L Semenza
Sep 3, 2004·Cancer Research·Kevin L Bennewith, Ralph E Durand
Sep 15, 2004·NMR in Biomedicine·Harold M SwartzTadeusz Walczak
Apr 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Huagang HouHarold M Swartz
Apr 6, 2006·Advances in Experimental Medicine and Biology·Huagang HouHarold M Swartz
Apr 6, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ken-ichiro MatsumotoMurali C Krishna
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Martyna ElasHoward J Halpern
Jul 25, 2006·Nature Reviews. Cancer·Andrew I Minchinton, Ian F Tannock
Apr 3, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hideo Sato-AkabaHiroshi Hirata
Apr 24, 2008·The Journal of Clinical Investigation·Shingo MatsumotoMurali C Krishna
May 14, 2008·International Journal of Radiation Oncology, Biology, Physics·Martyna ElasHoward J Halpern
May 27, 2008·Journal of Magnetic Resonance·Hideo Sato-AkabaHiroshi Hirata
Jul 2, 2008·Radiation Measurements·Ann Barry FloodHarold M Swartz
Jul 18, 2008·Cancer Research·Laura I Cárdenas-NaviaMark W Dewhirst
Sep 3, 2009·International Journal of Oncology·Fuminori HyodoJeeva P Munasinghe
Sep 10, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shunsuke IwanoYohei Miyamoto
Mar 12, 2010·Chemical Reviews·Rizwan Ahmad, Periannan Kuppusamy
Sep 21, 2010·Journal of Magnetic Resonance·R AhmadJ L Zweier
Oct 21, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Martyna ElasHoward J Halpern
Dec 17, 2010·Cancer Research·Shingo MatsumotoMurali C Krishna

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Citations

Nov 15, 2012·Nature Reviews. Clinical Oncology·Michael R HorsmanJens Overgaard
Dec 26, 2015·BMC Nutrition·Alexander B RabovskyBruno Fink
Nov 5, 2014·Contrast Media & Molecular Imaging·Pierre Danhier, Bernard Gallez
May 16, 2014·ChemMedChem·Quyen N DoA Dean Sherry
Aug 2, 2016·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ken-Ichiro Matsumoto
Sep 14, 2018·Magma·Céline Marie DesmetBernard Gallez
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Yi LiPi-Song Li
Aug 12, 2013·Methods and Applications in Fluorescence·Julian HofmannJonathan Jantsch
Apr 15, 2020·The British Journal of Radiology·Joseph WallerYasmin Hasan
Apr 24, 2017·Cell Biochemistry and Biophysics·Huagang HouPeriannan Kuppusamy
Jul 19, 2013·Cancer Research·Martyna ElasHoward J Halpern
Feb 2, 2021·Applied Magnetic Resonance·Joshua R Biller, Joseph E McPeak
Mar 12, 2021·International Journal of Radiation Biology·Rebecca A D'AlonzoMartin A Ebert
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ken-Ichiro MatsumotoMurali C Krishna

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Methods Mentioned

BETA
imaging techniques
imaging technique
nuclear magnetic resonance
NMR
xenograft
xenografts
biopsies

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