Electron paramagnetic resonance oxygen imaging of a rabbit tumor using localized spin probe delivery.

Medical Physics
Boris EpelHoward J Halpern

Abstract

Application of in vivo electron paramagnetic resonance (EPR) oxygen imaging (EPROI) to tumors larger than those of mice requires development of both instrumental and medical aspects of imaging. 250 MHz EPR oxygen imaging was performed using a loop-gap resonator with a volume exceeding 100 cm3. The paramagnetic spin probe was injected directly into the femoral artery feeding the rabbit leg/tumor. The authors present continuous wave and electron spin echo EPR oxygen images of a large size (4 cm) VX-2 tumor located on the leg of a New Zealand white rabbit. This study demonstrates the feasibility of continuous wave and electron spin echo oxygen imaging modalities for investigation of volumes of tumor and normal tissue relevant to large animals. The injection of the spin probe directly into the artery feeding a rabbit leg will allow one to reduce, by over one order of magnitude, the amount of spin probe used as compared to whole animal i.v. injection.

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Citations

Aug 17, 2011·Journal of Magnetic Resonance·Joshua R BillerGareth R Eaton
Jul 15, 2015·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·Gage RedlerHoward J Halpern
Sep 6, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Boris EpelHoward J Halpern
Feb 13, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gage RedlerHoward J Halpern
Aug 1, 2015·Journal of Magnetic Resonance·Zhiwei QiaoHoward Halpern
Oct 15, 2014·Journal of Magnetic Resonance·Zhiwei QiaoHoward J Halpern
Aug 9, 2016·Journal of Magnetic Resonance·Anthony G ChristodoulouBoris Epel
Oct 13, 2012·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Hiroshi Hirata
Aug 24, 2019·Cell Biochemistry and Biophysics·Michal GonetMartyna Elas
Feb 26, 2019·Concepts in Magnetic Resonance. Part B, Magnetic Resonance Engineering·Laura A BuchananGareth R Eaton
Feb 3, 2018·Applied Magnetic Resonance·George A RinardHoward J Halpern
Aug 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kevin KoppNico Fleck
Jun 9, 2020·The Journal of Physiology·Inna GertsenshteynHoward Halpern
Jan 7, 2021·Chemistry : a European Journal·Nico FleckOlav Schiemann

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