PMID: 590843Oct 1, 1977

Electron probe microanalysis in the study of gallstones

J M BeenD Lewis


Detailed information on the structure and composition of gallstones was obtained using an electron probe microanalyser in conjunction with the other methods. Gallstones were studied layer by layer without greatly disturbing the arrangement of the materials present. Elements, including trace elements such as copper, iron, and manganese, were identified and their distributions mapped. The range of the method was extended to determine the character and distribution of certain chemical groups present by treating sections of gallstone with reagents which contained easily detected elements. The nature of the bonding of the sulphur in the stones was studied by examining the sulphur-X-ray spectrum. Pigmented sulphur-containing deposits were found to contain sulphur in a low valence state but taurine conjugates and the sulphate groups of mucosubstances were not detected. Microcrystalline apatite present in the stones contained some manganese and seemed to be implicated in the absorption of the low valence sulphur compound and in the nucleation of some stones.


Aug 1, 1975·Gut·P M Bills, D Lewis
Nov 1, 1967·The Tohoku Journal of Experimental Medicine·N Nakamura
Dec 1, 1966·The Tohoku Journal of Experimental Medicine·N Nakamura
Jul 14, 1971·Journal of the American Chemical Society·M H O'Leary, G A Samberg


Oct 1, 1995·Digestive Diseases and Sciences·M H KimS P Lee
Mar 1, 1985·Calcified Tissue International·P M Bills
Sep 1, 2007·Indian Journal of Clinical Biochemistry : IJCB·P ChandranC S Pundir
Feb 1, 1988·Journal of Hepatology·A Ruiz de AguiarS Leguey Jimenez
Jul 1, 1993·Scandinavian Journal of Gastroenterology·D K AgarwalJ Kumar
Mar 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P F MaletN E Weston
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R C HarveyS M Strasberg
May 29, 2015·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Reinhard MoserReinhold Kerbl
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H S KaufmanK D Lillemoe
Apr 21, 1999·The Veterinary Record·R E RangdaleD J Alderman
Mar 9, 2012·World Journal of Hepatology·Vasiliy Ivanovich Reshetnyak

Related Concepts

Electron Probe Microanalysis
Scanning Electron Microscopy
Red Phosphorus
X-Ray Diffraction

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