Abstract
The blood-brain barrier has been proposed as an important site for the toxic action of lead in the central nervous system. To investigate this, capillary endothelial cells were isolated from rat cortex and exposed to lead in vitro. Tissue suspensions were then prepared for electron microscopy and X-ray microprobe analysis. In cells exposed in vitro to lead, electron-dense deposits were observed within mitochondria. With X-ray analysis, it was determined that these intramitochondrial deposits contained lead in a non-crystalline matrix. Also, lead appeared to be accumulated in the same intramitochondrial areas as calcium. The results suggest that lead is preferentially sequestered in mitochondria of capillary endothelial cells. Further, this selective localization may be associated with lead-induced disruptions in intracellular calcium metabolism and transepithelial transport processes.
References
Oct 1, 1977·Experimental and Molecular Pathology·J Walton, I K Buckley
Jan 1, 1979·The Journal of Physiology·G W Goldstein
Nov 4, 1977·Brain Research·G W Goldstein
Apr 1, 1978·Journal of Microscopy·T Barnard, L Sevéus
May 19, 1978·Brain Research·A D ToewsP Morell
Jun 16, 1978·Brain Research·E K Silbergeld, H S Adler
Mar 1, 1977·Annals of Neurology·G W GoldsteinJ Csejtey
Aug 26, 1977·Brain Research·A V Lorenzo, M Gewirtz
Sep 1, 1976·Chemico-biological Interactions·E Sabbioni, E Marafante
Dec 1, 1975·Environmental Health Perspectives·T W BouldinM R Krigman
Jun 1, 1966·Acta Neuropathologica·A Pentschew, F Garro
Apr 1, 1974·British Journal of Industrial Medicine·A P Hopkins, A D Dayan
Dec 1, 1974·Archives of Neurology·G W GoldsteinI Diamond
Apr 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·H Rasmussen, A Tenenhouse
Jan 1, 1974·Acta Neuropathologica·S RoyH M Zimmerman
May 11, 1973·Nature·J R Walton
Sep 1, 1970·The Biochemical Journal·A L Lehninger
Sep 5, 1970·Nature·K G CarrollR A Goyer
Citations
Jul 1, 1981·Archives of Toxicology·A W Klein, T R Koch
Oct 1, 1982·Toxicology and Applied Pharmacology·J G PoundsR L Kodell
Sep 1, 1990·Brain Research. Developmental Brain Research·M J Engle, J J Volpe
Jan 1, 1985·Neurochemistry International·F Joó
Oct 14, 2003·Toxicology and Applied Pharmacology·Wei ZhengJean-Francois Ghersi-Egea
Aug 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·M D Benson, J Price
Nov 1, 1987·Environmental Health Perspectives·T W Clarkson
Feb 8, 2000·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·B SzynakaA Augustynowicz
Dec 13, 2002·Brain : a Journal of Neurology·Theodore I Lidsky, Jay S Schneider
Jun 30, 1986·Toxicology and Applied Pharmacology·K MaxwellP A Cancilla
Feb 1, 1984·Teratology·M R Kuettel, S Kaplan
Jan 1, 1996·Journal of Advanced Nursing·H H Yung
Mar 1, 1984·The American Journal of Physiology·J B Pickett, J C Bornstein