Electron resonance studies on the influence of anionic surfactants on human skin

Dermatology : International Journal for Clinical and Investigative Dermatology
Y KawasakiH I Maibach

Abstract

When skin is exposed to chemicals, raw materials interact with the lipid structure of the stratum corneum. At least two types of disorders can be distinguished--that of alkyl chains inside one lipid bilayer and that of lipid layer arrangement. Electron spin resonance (ESR) spectroscopy of a nitroxide spin label is a valuable method in the study of biological membranes. These experiments define the effect of anionic surfactants on the lipid bilayer of human stratum corneum. 5-Doxyl stearic acid (5-DSA) was used as the spin label. Sodium lauryl sulfate (SLS) and sodium lauroyl-L-glutamate (SLG) were the anionic surfactants studied. ESR spectrum measurements of surfactant-treated stratum corneum were performed and order parameters calculated. 1% of SLS leads to an obvious change in ESR spectra--from strongly to weakly immobilized spectra. The molecular motion of spin labels (5-DSA) in SLS-treated stratum corneum is different from that of spin labels in the untreated stratum corneum. The ESR spectra suggest that SLS affects the spin label binding to the lipid membrane and causes an increase in the mobility of bilayers. On the other hand, there were minimal changes in ESR spectra of 1% of SLG-treated stratum corneum. An increase in ...Continue Reading

Citations

Mar 8, 2000·International Journal of Pharmaceutics·J MizushimaH I Maibach
Sep 6, 2001·Clinics in Dermatology·R WolfY Tüzün
Jun 10, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Kenichi SakaiMasahiko Abe
Nov 18, 2006·The Journal of Investigative Dermatology·Eiichiro YagiKouichi Nakagawa
May 13, 2008·International Journal of Pharmaceutics·Zrinka AbramovićJulijana Kristl
Jan 20, 2004·Dermatologic Therapy·Syed AbbasMichael Massaro
Nov 3, 2010·Biochimica Et Biophysica Acta·Paulo S C PretéShirley Schreier

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