PMID: 6254101Jan 1, 1980

Electron spin resonance spin-label studies of mouse olfactory epithelium

Physiological Chemistry and Physics
A D ClarkS J Wyard

Abstract

Three classes of interaction of spin-labeled odors with olfactory membrane of mouse were identified by electron spin resonance spectroscopy and correlated with the olfactory potencies of those odors. Also, variation of fluidity in this membrane was probed using spin-labeled lipids in which the nitroxide group was at increasing distances from the lipid headgroup. A cooperative model of olfactory transduction in agreement with the results is introduced, and typical dose response curves are computed that can predict molecular features necessary for a strong odor.

Related Concepts

Ethyl acetate
Diethyl ketone, 3-(14)C-labeled cpd
Acetaldehyde
Acetic Acids
Membrane Fluidity
Cell Surface Proteins
Odors
Olfactory Epithelium
Pentanones
Spin Labels

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