PMID: 3036703Jun 1, 1987Paper

Electron spin resonance studies of erythrocytes from spontaneously hypertensive rats and humans with essential hypertension

Hypertension
K TsudaY Masuyama

Abstract

The purpose of the present study was to investigate erythrocyte membrane abnormalities in hypertension by means of an electron spin resonance and spin-label technique. The erythrocytes from spontaneously hypertensive rats (SHR) and humans with untreated essential hypertension were examined and compared with their normotensive counterparts, and electron spin resonance spectra were obtained for a fatty spin-label agent (5-nitroxy stearate) incorporated into the erythrocyte membranes. The value of outer hyperfine splitting (2T' parallel) was significantly higher in erythrocytes of SHR and humans with essential hypertension than in erythrocytes of normotensive controls (at 37 degrees C: SHR, 56.14 +/- 0.51 gauss [G], n = 8; Wistar-Kyoto rats, 52.22 +/- 0.86 G, n = 4, p less than 0.01; humans with essential hypertension, 56.94 +/- 0.27 G, n = 11; normotensive subjects, 55.44 +/- 0.36 G, n = 8, p less than 0.01). The order parameter (S) was also increased in the hypertensive rats and humans compared to their respective normotensive controls. When calcium was loaded to erythrocytes with calcium ionophore A23187 (0.9 microM) and CaCl2 (1.0 mM), the parameters of the spectra were increased. These changes were more prominent in the hyper...Continue Reading

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Citations

Dec 7, 2010·The Journal of Membrane Biology·Vladimir AjdžanovićVerica Milošević
Jun 21, 2001·Hypertension Research : Official Journal of the Japanese Society of Hypertension·K TsudaY Masuyama
May 1, 2009·Acta Diabetologica·Ismael H Pérez-HernándezRicardo Mejía-Zepeda
Mar 3, 2010·European Journal of Pharmacology·Kentarou UshijimaAkio Fujimura
Dec 1, 1991·Hypertension·A F DominiczakD F Bohr
Sep 14, 2007·Molecular Membrane Biology·Jesús PradesFrancisca Barceló
Jul 16, 2003·Clinical and Experimental Pharmacology & Physiology·Kazushi TsudaIchiro Nishio
Mar 13, 2015·American Journal of Physiology. Renal Physiology·Yu LiuRajeev Rohatgi

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