PMID: 9422581Jan 9, 1998Paper

Electron wedges for radiation therapy

International Journal of Radiation Oncology, Biology, Physics
E P LiefJ L Humm

Abstract

Brain tumors can be advantageously treated with electron over photon radiation, by exploiting the rapid fall-off in dose with depth. This advantage could be further enhanced by utilizing multiple electron beams. However, in some beam configurations, wedged dose profiles would be necessary for the dose uniformity. Unlike photons, shaped pieces of material placed in electron beam severely degrade the energy, give additional scattering and, therefore, are suboptimal. The purpose of this study was to create wedged electron fields, using intensity modulation. The combination of electron wedges enables a more uniform coverage of brain tumors with a reduced dose to normal tissue. Intensity modulation was performed for 10 to 50 MeV electrons using a narrow scanning elementary beam of a racetrack Microtron accelerator, delivering radiation pulses with coordinates and intensities prescribed by a custom scan matrix. Dispensing more pulses (or longer pulses) within the field to increase the local dose, one can sharpen the penumbra at depth and generate wedged dose distributions of arbitrary angle as well as many other desired profiles. We modulated the electron beams, measured dose distributions using film in an anthropomorphic phantom, an...Continue Reading

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Citations

Nov 13, 2001·International Journal of Radiation Oncology, Biology, Physics·UNKNOWN Intensity Modulated Radiation Therapy Collaborative Working Group
Jan 5, 2002·International Journal of Radiation Oncology, Biology, Physics·Erik W KorevaarAnders Brahme
May 18, 2004·International Journal of Radiation Oncology, Biology, Physics·Shiva K DasJulian G Rosenman

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