Electronegative LDL and lipid abnormalities in patients undergoing hemodialysis and peritoneal dialysis

Nephron. Clinical Practice
Julie Calixto LoboDulcineia S P Abdalla

Abstract

Oxidative modification of low-density lipoprotein (LDL) has been demonstrated in patients with end-stage renal disease, where it is associated with oxidative stress and plays a key role in the pathogenesis of atherosclerosis. In this context, the generation of minimally oxidized LDL, also called electronegative LDL [LDL(-)], has been associated with active disease, and is a detectable sign of atherogenic tendencies. The purpose of this study was to evaluate serum LDL(-) levels and anti-LDL(-) IgG autoantibodies in end-stage renal disease patients on dialysis, comparing patients on hemodialysis (HD), peritoneal dialysis (PD) and a control group. In addition, the serum lipid profile, nutritional status, biochemical data and parameters of mineral metabolism were also evaluated. The serum levels of LDL(-) and anti-LDL(-) IgG autoantibodies were measured in 25 patients undergoing HD and 11 patients undergoing PD at the Centro Integrado de Nefrologia, Rio de Janeiro, Brazil. Ten healthy subjects served as a control group. Serum levels of albumin, total cholesterol, triglycerides and lipoproteins were measured. Calculations of subjects' body mass index and measurements of waist circumference, triceps skin fold and arm muscle area were...Continue Reading

Citations

Jun 4, 2014·Current Atherosclerosis Reports·Liang-Yin KeChu-Huang Chen
Dec 20, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Viviane O LealDenise Mafra
Jul 12, 2011·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Julie Calixto LoboDenise Mafra
Jun 16, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andreza O SantosMaria C O Izar
Jun 17, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Julie Calixto LoboJoão Paulo Machado Torres
Mar 16, 2012·Renal Failure·Viviane O LealDenise Mafra
Feb 5, 2011·Atherosclerosis·Ana Paula Queiroz MelloNágila Raquel Teixeira Damasceno
Jul 6, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marcela Frota CavalcanteDulcineia Saes Parra Abdalla
Jan 30, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Denise MafraMaurilo Leite

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