Electronegative low-density lipoprotein subfraction from type 2 diabetic subjects is proatherogenic and unrelated to glycemic control

Diabetes/metabolism Research and Reviews
Sonia BenítezJordi Ordóñez-Llanos

Abstract

The physicochemical and biological characteristics of electronegative low-density lipoprotein (LDL) (LDL(-)) from type 2 diabetic patients (DM2), before and after insulin therapy, were studied. Total LDL was subfractionated in LDL(+) (native LDL) and LDL(-) by anion-exchange chromatography. The proportion of LDL(-) was increased in plasma from DM2 patients compared to control subjects (13.8 +/- 4.6% versus 6.1 +/- 2.5, P < 0.05) and was not modified after glycemic optimization (14.0 +/- 5.9%). LDL(-) from DM2 patients presented similar differential characteristics versus LDL(+) than LDL(-) from controls; that is, decreased apoB and oxidizability, and increased triglyceride, nonesterified fatty acids (NEFA), apoE, apoC-III, platelet-activating factor (PAF) acetylhydrolase activity and aggregability. No difference in particle size, antioxidants, malondialdehyde (MDA), fructosamine or glycated low-density lipoprotein (gLDL) was observed between LDL subfractions. Concerning differences between LDL subfractions isolated from DM2 and from control subjects, the former showed increased MDA, fructosamine and gLDL proportion and decreased LDL size and antioxidant content. The only effect of glycemic optimization was a decrease in fructos...Continue Reading

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Citations

Sep 26, 2013·Mediators of Inflammation·Montserrat EstruchSònia Benítez
Jun 4, 2014·Current Atherosclerosis Reports·Liang-Yin KeChu-Huang Chen
Apr 3, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·José Luis Sánchez-Quesada, Antonio Pérez
Apr 20, 2007·Biochimica Et Biophysica Acta·Sònia BenítezJose Luis Sánchez-Quesada
Feb 5, 2011·Atherosclerosis·Ana Paula Queiroz MelloNágila Raquel Teixeira Damasceno
Jul 6, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marcela Frota CavalcanteDulcineia Saes Parra Abdalla
Sep 12, 2012·Current Opinion in Lipidology·José L Sánchez-QuesadaJordi Ordóñez-Llanos
Apr 15, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Shobini JayaramanOlga Gursky

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