Electronic barcoding of a viral gene at the single-molecule level.

Nano Letters
Alon SingerAmit Meller

Abstract

A new single-molecule approach for rapid and purely electronic discrimination among similar genes is presented. Combining solid-state nanopores and γ-modified synthetic peptide nucleic acid probes, we accurately barcode genes by counting the number of probes attached to each gene and measuring their relative spacing. We illustrate our method by sensing individual genes from two highly similar human immunodeficiency virus subtypes, demonstrating feasibility of a novel, single-molecule diagnostic platform for rapid pathogen classification.

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Citations

Oct 3, 2013·ACS Nano·Joseph LarkinMeni Wanunu
Nov 5, 2013·Nature Nanotechnology·Nicolas Di FioriAmit Meller
Jul 6, 2014·PloS One·Michael M MarshallAdam R Hall
Jan 23, 2016·Analytical Chemistry·Hongwen WuQuanjun Liu
Jul 25, 2015·ACS Applied Materials & Interfaces·Colin R CrickJoshua B Edel
Jun 26, 2015·Scientific Reports·Allison SquiresAmit Meller
Nov 12, 2014·Analytical Chemistry·Masateru Taniguchi
Feb 5, 2015·Nature Communications·Xu LiuDerek Stein
Dec 17, 2014·Nano Letters·Calin PlesaCees Dekker
Oct 23, 2013·Journal of the American Chemical Society·Allison H SquiresAmit Meller
May 7, 2016·PloS One·Trevor J MorinWilliam B Dunbar
Nov 9, 2017·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Tarun JainRohit Karnik
Sep 23, 2014·Chemical Communications : Chem Comm·Nagarjun NarayanaswamyT Govindaraju
Feb 17, 2015·The Analyst·Tal Gilboa, Amit Meller
May 2, 2015·Electrophoresis·Matthew WaughVincent Tabard-Cossa
Oct 20, 2018·Small·Yuning ZhangWilliam B Dunbar
Apr 4, 2019·Advanced Materials·Joshua D SpitzbergAmit Meller
Feb 2, 2019·Annual Review of Analytical Chemistry·Tim Albrecht
Oct 31, 2012·Electrophoresis·Evrim AtasAmit Meller
Jun 6, 2015·Electrophoresis·Jiri KudrRene Kizek
Nov 2, 2017·Clinical Chemistry·Vikram S Kumar, Molly Webster
Dec 4, 2012·Lab on a Chip·Joshua W GriffisRobert H Meltzer
Dec 1, 2012·Nanoscale·Niraj ModiUlrich Kleinekathöfer
Nov 13, 2015·PloS One·Allison H SquiresAmit Meller
Sep 28, 2018·Advanced Materials·Kidan LeeKi-Bum Kim
Jan 4, 2019·Nature Communications·Ke LiuAleksandra Radenovic
Oct 22, 2019·Advanced Functional Materials·Nitinun VarongchayakulMark Grinstaff
Dec 1, 2018·Cellular and Molecular Life Sciences : CMLS·Shipra MalikRaman Bahal
Feb 3, 2015·Nanotechnology·Spencer Carson, Meni Wanunu
Sep 1, 2017·Nature Communications·Nicholas A W BellUlrich F Keyser

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