PMID: 3755122May 1, 1986Paper

Electronic spreadsheet program for estimating two-compartment intravenous pharmacokinetic parameters by least squares linear regression analysis

International Journal of Bio-medical Computing
R A HolmesJ W McCall

Abstract

A microcomputer program using an electronic spreadsheet program was developed to calculate pharmacokinetic values of thiacetarsamide sodium, a drug used to kill the adult heartworm (Dirofilaria immitis) parasite of the dog. A least squares, semilogarithmic regression analysis was done on data using a two compartment intravenous model. The data entered includes the time after injection and the drug concentration at that time. A graph of the points can be viewed or plotted, with the time on the x-axis, and the natural log of the drug concentration on the y-axis. The program was developed on a Televideo (512 kbytes) microcomputer. The spreadsheet used was Lotus 123 with the pharmacokinetics program occupying 16 kbytes of memory (720 cells) out of the 400 kbytes available with Lotus.

References

Jan 1, 1977·European Journal of Clinical Pharmacology·H M von HattingbergG Kreuter
Feb 1, 1983·Computer Programs in Biomedicine·G S LandrianiM Rocchetti
Jan 1, 1983·Computers in Biology and Medicine·E G Oestreicher, G F Pinto

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Citations

Jan 1, 1987·Computers in Biology and Medicine·C Sundqvist, K Enkvist
Jan 1, 1989·Computers in Biology and Medicine·C SundqvistS Hodges

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