PMID: 6977982Jan 1, 1982Paper

Electronystagmographic findings in rats exposed to styrene or toluene

Acta Oto-laryngologica
R ThamC Liedgren

Abstract

A previously described experimental model for studying the effect of industrial solvents in the vestibular system of rabbits has been applied to rats. To achieve a constant concentration, the solvent was infused intravenously, dissolved in a lipid emulsion. Arterial blood levels were estimated by gas chromatography. The vestibulo-oculomotor behaviour of rats during repeated rotatory acceleration was investigated by electronystagmography. The effect of two solvents-toluene and styrene-on the rotatory induced nystagmus was examined. Both solvents caused an exaggerated reaction at arterial blood levels above 75 ppm. The investigation indicated that the rat will be suitable species for further electronystagmographic investigation of the influence of organic solvents on the vestibular system, for example in screening studies of the toxicity of these solvents.

References

Nov 1, 1977·Acta Oto-laryngologica·G AschanR Tham
May 1, 1979·Acta Pharmacologica Et Toxicologica·R ThamA Bertler
Jan 1, 1979·Advances in Oto-rhino-laryngology·L M OdkvistG Aschan
Jan 1, 1979·Acta Oto-laryngologica·A J FischerW Kuijpers
Jul 1, 1977·Chemico-biological Interactions·H Savolainen
Apr 1, 1979·Acta Pharmacologica Et Toxicologica·K Savolainen, M Linnavuo
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Oct 31, 1978·Archives of Oto-rhino-laryngology·M SasaI Matsuoka
Dec 1, 1975·Scandinavian Journal of Work, Environment & Health·I Astrand
Jan 1, 1963·Acta Oto-laryngologica. Supplementum·C FERNANDEZ, J M FREDRICKSON

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Citations

Nov 1, 1982·Acta Oto-laryngologica·L M OdkvistS R Liedgren
Jan 1, 1988·Acta Oto-laryngologica. Supplementum·B I Wenngren, L M Odkvist
Jan 1, 1987·Scandinavian Audiology·L M OdkvistL M Bergholtz
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·R ThamL M Odkvist

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