Electropharmacology of antiarrhythmic drugs

American Heart Journal
M R Rosen, A L Wit

Abstract

Cardiac arrhythmias may be caused by abnormalities of impulse initiation, impulse propagation, or a combination of the two. The specific mechanisms that may induce arrhythmias are reviewed, as are the means whereby antiarrhythmic drugs might be expected to modify arrhythmias. The cellular electrophysiologic effects of the following antiarrhythmic drugs are discussed: quinidine, procainamide, disopyramide, lidocaine, tocainide, mexiletine, phenytoin, beta-blocking and slow-channel-blocking drugs, aprindine, bretylium, ethmozin, and amiodarone. A knowledge of the similarities and differences of their actions on the determinants of conduction, on repolarization and refractoriness, on automatic mechanisms, and on afterdepolarizations, when considered in the context of the mechanism of clinically occurring tachyarrhythmias, may provide the correct framework for the choice of an appropriate agent for the control of an individual disorder of rhythm. However, it is emphasized that neither the precise mechanism of various dysrhythmias nor the fundamental basis for the salutary action of antiarrhythmic compounds is completely understood.

References

May 1, 1977·Progress in Cardiovascular Diseases·G R Ferrier
Sep 1, 1977·Circulation Research·M Vassalle
Jun 1, 1979·Cardiovascular Research·R RuffyD P Zipes
Apr 1, 1978·The American Journal of Cardiology·E N MooreR A Moller
Oct 1, 1977·Circulation Research·A L Wit, P F Cranefield
Sep 1, 1976·European Journal of Pharmacology·N Goupil, J Lenfant
May 1, 1974·European Journal of Pharmacology·F VerdonckA Vleugels
Feb 1, 1968·Circulation Research·J T BiggerB F Hoffman
Jan 1, 1983·Pflügers Archiv : European journal of physiology·J W MasonB G Katzung
Jul 1, 1981·Circulation Research·B F Hoffman, M R Rosen
Dec 1, 1980·The American Journal of Cardiology·K H Dangman, B F Hoffman
Oct 1, 1960·Archives of Surgery·E HOFFMAN

❮ Previous
Next ❯

Citations

Nov 1, 1991·Journal of Clinical Pharmacology·M D Freedman, J C Somberg
Aug 31, 1987·The American Journal of Cardiology·P C DeedwaniaP Golden
May 30, 1989·European Journal of Pharmacology·D A LathropA Schwartz
Feb 1, 1989·Journal of the American College of Cardiology·W G StevensonD Wohlgelernter
Apr 1, 1984·Journal of the American College of Cardiology·D P ZipesJ J Heger
Nov 1, 1990·Pacing and Clinical Electrophysiology : PACE·P J Podrid
Oct 1, 1987·Journal of Veterinary Internal Medicine·E de MadronD H Knight
Feb 16, 1985·British Medical Journal·J K Aronson
Sep 26, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Colleen E ClancyYoram Rudy
Jun 20, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Huajun LiuRobert Kass
Nov 13, 2007·Journal of Electrocardiology·Zheng I Zhu, Colleen E Clancy
Nov 15, 2011·British Journal of Pharmacology·Herbert M HimmelErich Wettwer
Oct 19, 1988·The American Journal of Cardiology·P J PodridM D Klein
Mar 6, 1990·The American Journal of Cardiology·P J Podrid
Jun 5, 2003·Journal of Cardiovascular Electrophysiology·Simon P FynnClifford J Garratt
Jun 15, 1987·The American Journal of Cardiology·L K ToivonenH Frick
Feb 1, 1986·Anaesthesia·G SolaresM Buitrago
Dec 25, 2004·Physiological Reviews·Colleen E Clancy, Robert S Kass
Feb 6, 2004·Journal of Cardiovascular Electrophysiology·Michael R Franz
Jan 1, 1989·Basic Research in Cardiology·S S Sheu
Nov 1, 1988·Naunyn-Schmiedeberg's Archives of Pharmacology·M Aomine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.