Electrophoretic drug delivery for seizure control

Science Advances
Christopher M ProctorGeorge G Malliaras

Abstract

The persistence of intractable neurological disorders necessitates novel therapeutic solutions. We demonstrate the utility of direct in situ electrophoretic drug delivery to treat neurological disorders. We present a neural probe incorporating a microfluidic ion pump (μFIP) for on-demand drug delivery and electrodes for recording local neural activity. The μFIP works by electrophoretically pumping ions across an ion exchange membrane and thereby delivers only the drug of interest and not the solvent. This "dry" delivery enables precise drug release into the brain region with negligible local pressure increase. The therapeutic potential of the μFIP probe is tested in a rodent model of epilepsy. The μFIP probe can detect pathological activity and then intervene to stop seizures by delivering inhibitory neurotransmitters directly to the seizure source. We anticipate that further tailored engineering of the μFIP platform will enable additional applications in neural interfacing and the treatment of neurological disorders.

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Citations

Jan 9, 2019·Advanced Materials·Magnus BerggrenIgor Zozoulenko
Mar 13, 2019·Advanced Materials·Erica ZeglioAnna Herland
Mar 16, 2019·Lab on a Chip·Maria SeitanidouDaniel T Simon
Sep 14, 2019·Advanced Materials·Amy E RochfordDamiano G Barone
Oct 15, 2019·Advanced Materials·Florian FalleggerStéphanie P Lacour
Feb 28, 2020·Advanced Materials·Yei Hwan JungTae-Il Kim
Jun 6, 2020·Advanced Materials·Kai XiaoMarkus Antonietti
Apr 2, 2020·Bioelectronic Medicine·Bettina HabeltIvan Minev
Sep 11, 2019·Advanced Healthcare Materials·Maria SeitanidouDaniel T Simon
Oct 5, 2019·Advanced Healthcare Materials·Kevin M WoeppelXinyan Tracy Cui
Feb 8, 2019·Nature Reviews. Drug Discovery·Heike WulffVladimir Yarov-Yarovoy
Aug 8, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Matteo SolazzoMichael G Monaghan
Apr 30, 2020·Scientific Reports·Shao-Tuan ChenGeorge G Malliaras
Nov 17, 2020·Macromolecular Bioscience·Anna Herland, Myung-Han Yoon
Jan 31, 2021·Science Advances·X StrakosasD T Simon
Sep 29, 2020·Advanced Drug Delivery Reviews·Dinorath Olvera, Michael G Monaghan
Apr 27, 2021·Advanced Healthcare Materials·Yuxin LiuZhenan Bao
May 23, 2021·Biopolymers·Manping JiaMarco Rolandi
May 22, 2021·Advanced Healthcare Materials·Quanxia LyuWenlong Cheng
May 25, 2021·Chemical Reviews·Yuxiao LiuYuanjin Zhao
Jun 4, 2021·ACS Applied Materials & Interfaces·Min-Ah OhTaek Dong Chung
Jun 12, 2021·Frontiers in Bioengineering and Biotechnology·Manuele GoriGiovanni Di Pino
Jul 2, 2021·Advanced Materials Technologies·Linda WaldherrRainer Schindl
Mar 28, 2019·ACS Applied Materials & Interfaces·David J PoxsonDaniel T Simon
Feb 18, 2020·Chemistry of Materials : a Publication of the American Chemical Society·Christopher M ProctorGeorge G Malliaras
Dec 2, 2021·Advanced Healthcare Materials·Yang YangChangyou Zhan
Jan 21, 2022·Chemical Reviews·Magnus BerggrenKlas Tybrandt

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Methods Mentioned

BETA
electrophoresis
enzyme-linked immunosorbent assay

Software Mentioned

ZEN
LabVIEW
μFIP

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