PMID: 7992912Dec 1, 1994Paper

Electrophysiologic analysis of preemptive effects of spinal opioids on N-methyl-D-aspartate receptor-mediated events

Victoria ChapmanA H Dickenson


Spinal N-methyl-D-aspartate (NMDA) receptor-mediated mechanisms may contribute to reduced opioid sensitivity in conditions of pain. The effectiveness of spinal opioids in inhibiting NMDA-mediated nociceptive events was assessed with two models. In addition, opioid dose-response curves with preemptive administration were compared with early and late postadministrations. Dorsal horn nociceptive neuronal responses were recorded in the intact halothane anesthetized rat to acute repetitive C-fiber electrical stimulation (0.1 and 0.5 Hz) and to the peripheral injection of 5% formalin. At 0.5 Hz but not at 0.1 Hz, there was an enhanced C-fiber evoked response of dorsal horn neurons elicited by repetitive C-fiber stimulation (wind-up), which is mediated by the NMDA receptor. Formalin produced a biphasic response; the late protracted inflammatory phase was NMDA receptor-mediated. With 0.5-Hz stimulation a large degree of wind-up was elicited; it was less sensitive to 5 micrograms morphine compared with the effect of the same dose on the residual wind-up elicited at 0.1 Hz. Preadministration and early postadministration of morphine were equieffective at inhibiting the second-phase formalin response. In contrast, administration of the fas...Continue Reading


Mar 26, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·M E Abdel-GhaffarA Anwar
Jan 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C S WongS T Ho
Jul 4, 2002·Current Pain and Headache Reports·Roland Staud, Michael L Smitherman
Feb 20, 2003·European Journal of Pharmacology·Natalia SevostianovaWojciech Danysz
Mar 3, 1998·Progress in Neurobiology·G Baranauskas, A Nistri
Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·María Rodríguez-MuñozJavier Garzón
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Jul 22, 2009·Rinshō shinkeigaku = Clinical neurology·Yanosuke KouzakiMakoto Uchino
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