PMID: 3760368Oct 1, 1986Paper

Electrophysiologic and antiarrhythmic efficacy of oral sotalol for sustained ventricular tachyarrhythmias: evaluation by programmed stimulation and ambulatory electrocardiogram

Journal of the American College of Cardiology
G SteinbeckR Haberl

Abstract

Programmed ventricular stimulation and ambulatory electrocardiography were performed both before and during oral sotalol therapy in 39 patients with ventricular tachyarrhythmia inducible by programmed stimulation (sustained ventricular tachycardia [n = 31], ventricular fibrillation [n = 3], nonsustained ventricular tachycardia [n = 5]). Oral sotalol was started at 80 mg twice daily and the dose thereafter was then gradually increased until a mean daily dose of 300 mg (range 160-480) was reached. In 12 of 34 patients with inducible sustained ventricular tachycardia or fibrillation the arrhythmia was suppressed; in 19 patients it was not and in 3 the spontaneous arrhythmia recurred. Reproducibly inducible nonsustained ventricular tachycardia was suppressed by sotalol in all five patients with this arrhythmia. Thus, a favorable electrophysiologic response was obtained in 17 (44%) of 39 patients. Arrhythmia suppression correlated with the type of arrhythmia (unsustained or sustained) induced during the control period (p less than 0.05), and nonresponders had a higher incidence of previously ineffective drug trials (p less than 0.05). In 22 patients treated long term with sotalol suppression of arrhythmia inducibility on programmed ...Continue Reading

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Citations

Oct 1, 1990·Cardiovascular Drugs and Therapy·H J TrappeP Lichtlen
Apr 1, 1989·Journal of the American College of Cardiology·S NattelM Talajic
Jan 1, 1989·Journal of the American College of Cardiology·M A RuderR A Winkle
Jul 1, 1993·Journal of the American College of Cardiology·P DorianJ Mitchell
Aug 29, 1996·The American Journal of Cardiology·P A O'Callaghan, B A McGovern
May 1, 1995·Progress in Cardiovascular Diseases·E Cavusoglu, W H Frishman
Dec 1, 1988·Journal of the American College of Cardiology·R GonzalezH Sharkey
Aug 1, 1997·Journal of the American College of Cardiology·W HaverkampM Borggrefe
May 1, 1988·Journal of the American College of Cardiology·S M YabekB N Singh
Jul 7, 1994·The New England Journal of Medicine·S H Hohnloser, R L Woosley
Mar 1, 1995·Pacing and Clinical Electrophysiology : PACE·S L Winters, J H Curwin
Mar 1, 1995·Pacing and Clinical Electrophysiology : PACE·J P Claudel, P Touboul
Feb 1, 1993·Journal of Cardiovascular Electrophysiology·R Ruffy
Jan 2, 1990·The American Journal of Cardiology·L F SoykaR B Spangenberg
Feb 1, 1988·Pacing and Clinical Electrophysiology : PACE·E N Prystowsky
Mar 12, 1999·The American Journal of Cardiology·S Chandrasekaran, J S Steinberg
Sep 1, 1988·The American Journal of Cardiology·S N SinghR D Fletcher
Oct 21, 2016·American Journal of Therapeutics·Sahan P Semasinghe BandaralageSelvanayagam Niranjan
Nov 1, 1988·Pacing and Clinical Electrophysiology : PACE·L N Horowitz
Mar 1, 1994·Pacing and Clinical Electrophysiology : PACE·D BöckerM Borggrefe
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·B N Singh
Aug 3, 2001·Cardiovascular Drug Reviews·M Manoach, N Tribulova

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