PMID: 16508424Mar 2, 2006Paper

Electrophysiologic and retinal penetration studies following intravitreal injection of bevacizumab (Avastin)

Retina
Jonathan ShaharAnat Loewenstein

Abstract

Intravitreal bevacizumab (Avastin; Genentech Inc., San Francisco, CA) is a new treatment for age-related macular degeneration. The aim of this study was to evaluate retinal penetration and toxicity of bevacizumab. Ten albino rabbits were injected intravitreally with 0.1 mL (2.5 mg) of Avastin into one eye and 0.1 mL saline into the fellow eye. The electroretinogram (ERG) was recorded after 3 hours, 3 days, and 1, 2, and 4 weeks. The visual evoked potential (VEP) was recorded after 4 weeks. Confocal immunohistochemistry was used to assess retinal penetration. The ERG responses of the control and experimental eyes were similar in amplitude and pattern throughout the follow-up period. The flash VEP responses of the experimental eyes were of normal pattern and amplitude and did not differ from those recorded by stimulation of the control eye alone. Full thickness retinal penetration was present at 24 hours and was essentially absent at 4 weeks. Bevacizumab was found to be nontoxic to the retina of rabbits based on electrophysiologic studies. Full thickness retinal penetration may explain observed clinical effects of intravitreal bevacizumab. Although it is difficult to directly extrapolate to humans, our study supports the safe use...Continue Reading

References

Nov 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K N JonesR D Pearson
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Timothy L JacksonJohn Marshall
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Dec 31, 2004·The New England Journal of Medicine·Evangelos S GragoudasUNKNOWN VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group
Feb 4, 2005·Retina·Anthony P Adamis, David T Shima
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Herbert I HurwitzFairooz Kabbinavar

❮ Previous
Next ❯

Citations

Jun 10, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F ZiemssenS Grisanti
Jul 27, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M KerntA Kampik
Sep 11, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U SchraermeyerK U Bartz-Schmidt
Oct 28, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M MaierC P Lohmann
Nov 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ratimir Lazic, Nikica Gabric
Dec 1, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rodrigo JorgeIngrid U Scott
Dec 23, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S AisenbreyK U Bartz-Schmidt
Mar 3, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Rogério A CostaIngrid U Scott
Sep 6, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Alfredo AdánJuan José Molina
Aug 4, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Lihteh WuUNKNOWN Pan American Collaborative Retina Group (PACORES)
Aug 11, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eun Jee ChungHyoung Jun Koh
Jun 5, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Mitzy E Torres-SorianoHugo Quiroz-Mercado
Nov 5, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Panagiotis G TheodossiadisIoannis A Vergados
Aug 1, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Saloomeh SaatiMark S Humayun
Jun 10, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Christina Gerth
May 24, 2008·Eye·D J Pieramici, M D Rabena
Jul 22, 2006·Eye·C Canning, A Lotery
Nov 2, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jost B JonasFrank Schlichtenbrede
Oct 28, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Gholam A PeymanRichard Fiscella
Dec 24, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Vikram S BrarKakarla V Chalam
Dec 25, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yoko MiuraTakashi Kitaoka
Aug 4, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kayako MatsuyamaKanji Takahashi
Jun 3, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Banu Turgut OzturkSuleyman Okudan
Dec 3, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ali SalehiZahra Naderi Beni
Dec 14, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Tamer A Macky, Mohamed M Mahgoub
Apr 11, 2007·Retina·Catherine B MeyerleLawrence A Yannuzzi

❮ Previous
Next ❯

Related Concepts

Related Feeds