PMID: 6164285May 1, 1981Paper

Electrophysiologic effects of N-acetylprocainamide in human beings

The American Journal of Cardiology
P JaillonR A Winkle

Abstract

The electrophysiologic properties of N-acetylprocainamide (NAPA) were studied in 10 patients undergoing cardiac catheterization. Each patient received two successive intravenous infusions: one loading infusion over 15 minutes and one maintenance infusion at a slower rate for 30 minutes. Eight patients received 10.5 mg/kg body weight and two received larger doses (16 and 21 mg/kg, respectively). NAPA plasma concentration was measured at 5 minute intervals from 0 to 25 minutes, and then at 15 and 30 minutes of the second infusion. Mean blood pressure and electrophysiologic data obtained by programmed stimulation were recorded before drug administration and at 15 and 30 minutes of the infusion when the concentration of NAPA was nearly constant in each patient (range 12 to 35 microgram/ml). NAPA decreased blood pressure (p less than 0.005), increased corrected Q-T interval (p less than 0.01) and increased the atrial and ventricular effective refractory periods from 267 +/- 40 to 307 +/- 41 ms (p less than 0.01) and from 278 +/- 37 to 301 +/- 32.8 ms (p less than 0.05), respectively. NAPA did not significantly change sinus cycle length or sinus nodal recovery time, conduction intervals (A-H, H-V, P-R, QRS), atrioventricular nodal fu...Continue Reading

References

Dec 20, 1979·The New England Journal of Medicine·R LahitaM M Reidenberg
Sep 1, 1977·Circulation·J A KastorL N Horowitz
Mar 22, 1976·European Journal of Clinical Pharmacology·K FrislidP K Lunde
Jun 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·D E DrayerR W Sevy
Jan 1, 1981·The American Journal of Cardiology·R A WinkleF Peters
Dec 1, 1974·British Journal of Clinical Pharmacology·E KarlssonF Sjöqvist

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Citations

Jul 1, 1992·Journal of Clinical Pharmacology·R L Williams
Feb 1, 1985·American Heart Journal·D M Roden, R L Woosley
Dec 1, 1982·The American Journal of Cardiology·B OlshanskyS Hunt
Jan 1, 1983·Pharmacology & Therapeutics·D M Roden, R L Woosley
Jan 1, 1986·Journal of the American College of Cardiology·V TorresJ C Somberg
Dec 5, 1989·The American Journal of Cardiology·P Jaillon, M Drici
Sep 22, 1983·The American Journal of Cardiology·R L Woosley, D M Roden
Dec 1, 1982·The American Journal of Medicine·S C Vlay, P R Reid
Jan 1, 1989·Pacing and Clinical Electrophysiology : PACE·T FurukawaJ W Lister
Jul 1, 1984·Journal of Clinical Pharmacology·R L WoosleyD M Roden

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