PMID: 6112771Jan 1, 1981Paper

Electrophysiologic interactions of antipsychotic drugs with central noradrenergic pathways

Psychopharmacology
J MarwahaR Freedman

Abstract

The pathway from the nucleus coeruleus to Purkinje neurons in rat cerebellar cortex was used to analyze effects of antipsychotic neuroleptic drugs on a central noradrenergic pathway. Fluphenazine and haloperidol produced a dose-dependent increase in Purkinje neuron spontaneous discharge. This effect was not seen in animals in which the noradrenergic input had been removed by the neurotoxin 6-hydroxydopamine. In contrast, the effects of neuroleptics were still present in animals which had received neonatal X-ray irradiation, which destroys intrinsic inhibitory and excitatory pathways in cerebellar cortex. Chlorpromazine produced the same increase in discharge rate, but was significantly less potent. alpha-Flupenthixol was equipotent with fluphenazine, but beta-flupenthixol, a behaviorally inactive stereoisomer, was without effect. The dose-response curves showed potencies similar to those in several animal behavioral paradigms. In addition, the rank order of potency was identical to that in clinical tests of antipsychotic activity. Three-week chronic administration of fluphenazine resulted in complete blockage of noradrenergic activity, with no further increase in Purkinje neurons spontaneous discharge rate by additional doses o...Continue Reading

References

May 1, 1975·Journal of Neurobiology·R Freedman, B J Hoffer
Jan 1, 1977·Annals of the New York Academy of Sciences·M E Scheibel, A B Scheibel
Nov 14, 1977·European Journal of Clinical Pharmacology·C E ByeF Plowman
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Oct 1, 1972·Electroencephalography and Clinical Neurophysiology·H M Geller, D J Woodward
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·Y C Clement-CormierP Greengard
Jan 18, 1980·Science·C R LakeW E Bunney
Jan 1, 1963·Acta Pharmacologica Et Toxicologica·A CARLSSON, M LINDQVIST

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Citations

Jan 1, 1982·Psychopharmacology·M R PalmerT V Dunwiddie
Oct 1, 1992·Neuropharmacology·C L MillerR Freedman
Jan 1, 1982·Progress in Neurobiology·S L Peterson, T E Albertson
Jan 1, 1983·The International Journal of Neuroscience·J H Pirch, M J Corbus

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