PMID: 9178618Jul 1, 1997Paper

Electrophysiological actions of quinine on voltage-dependent currents in dissociated rat taste cells

Pflügers Archiv : European journal of physiology
Y Chen, M S Herness

Abstract

How taste receptor cells participate in encoding disparate compounds into distinct taste qualities represents a fundamental problem in the study of gustatory transduction mechanisms. Quinine is the most common stimulus employed to represent bitterness yet its electrophysiological consequences on voltage-dependent ion channels in the taste receptor cell have not been elucidated in detail. This study examines such effects on taste receptor cells dissociated from the foliate and circumvallate papillae of the rat. Outward potassium currents, which include transient, sustained and calcium-activated components, were reversibly inhibited by bath application of quinine, with an IC50 of 5.1x10(-6)M. The time course of the current traces, along with voltage shifts in normalized conductance and inactivation curves, suggests that multiple mechanisms of inhibition may be occurring. Inwardly rectifying potassium currents were unaffected. Sodium currents, to somewhat higher concentrations of quinine (IC50 = 6.4x10(-5)M), were also reduced in magnitude without noticeable effects on activation or reversal potential but with a shift in inactivation. Calcium currents, visualized with barium as a charge carrier, were enhanced in magnitude by the p...Continue Reading

Citations

Jan 25, 2003·Brain Research·Kyungpyo ParkJoong-Soo Kim
Jul 31, 2003·Progress in Biophysics and Molecular Biology·Albertino BigianiFrancesca Fieni
Oct 24, 2002·Journal of Neuroscience Methods·Harris RippsJane Zakevicius
Apr 12, 2002·Progress in Neurobiology·Albertino Bigiani
Dec 17, 2010·Assay and Drug Development Technologies·R Kyle PalmerRobert Bryant
Sep 2, 2005·Chemical Senses·Cedrick D DotsonAlan C Spector
Apr 1, 1999·Annual Review of Physiology·M S Herness, T A Gilbertson
Nov 26, 2009·Science in China. Series C, Life Sciences·PeiHua ChenJianHong Luo
Aug 11, 2006·Journal of Neurophysiology·Laura C Geran, Susan P Travers
Jun 19, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Fang-Li ZhaoScott Herness
Jul 17, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Ingo StaudacherDierk Thomas

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