Jul 1, 1981

Electrophysiological analysis of inhibitory synaptic mechanisms in the preoptic area of the rat

The Journal of Physiology
M L Mayer


1. Extracellular recordings were made from single neurones in the medial preoptic-anterior hypothalamus of rats anaesthetized with urethane or pentobarbitone 2. Stimulation of the arcuate--ventromedial area evoked inhibition in 76% of neurones; inhibition occurred as the initial response in 26% of neurones, followed orthodromic excitation in 26% and antidromic excitation in 24%. Stimulation of the periaqueductal grey evoked inhibition as the initial response in 63% of neurones. 3. Stimulation of both the arcuate--ventromedial area and the periaqueductal grey generated synaptically evoked high-frequency discharges in a few neurones. 4. Short ionophoretic pulses of beta-alanine, gamma-aminobutyric acid (GABA), glycine and taurine inhibited the discharge of most preoptic-anterior hypothalamic neurones. Bicuculline methochloride and picrotoxin antagonized both GABA responses and synaptic inhibition. Strychnine antagonized beta-alanine, glycine and taurine responses without altering synaptic inhibition. 5. Reduction of hypothalamic serotonin (5-HT) levels to about 40% of control values by micro-injection of 5,7-dihydroxytryptamine into the ventral tegmental area, or parenteral injection of parachlorophenylalanine, did not alter the ...Continue Reading

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Mentioned in this Paper

Neural Inhibition
August Rats
Preoptic Areas
Organum Vasculosum Laminae Terminalis
Potentials, Event-Related

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