Electrophysiological and endocrinological aspects of aging in the rat pineal gland

Neuroendocrinology
S ReussL Vollrath

Abstract

Previous morphological and biochemical studies point to an age-dependent loss of pineal gland function. In order to investigate the possible alterations of electrical activity of aged rat pineal glands, electrophysiological recordings in 3- and 18-month-old male Sprague-Dawley rats were undertaken at both daytime and nighttime. Extracellularly recorded action potentials were characterized according to discharge frequency and serum melatonin levels were determined concomitantly. Significant differences in the frequency distributions between young adult and old rats were found to occur at nighttime, with a shift towards lower frequencies in old animals. Serum melatonin levels were reduced significantly in old rats and the characteristic nocturnal peak was attenuated. These results demonstrate a distinct decrease of pineal electrical and secretory activity with advancing age, which may contribute to an age-dependent decline of neuroendocrine capacity.

Citations

Jan 1, 1995·Neuroscience and Biobehavioral Reviews·B L Myers, P Badia
Jan 1, 1993·Psychoneuroendocrinology·B R Grad, R Rozencwaig
Mar 1, 1991·Brain Research Bulletin·T AzekawaY Morita
Dec 23, 1998·Neuroscience and Biobehavioral Reviews·B Barrera-Mera, E Barrera-Calva
Oct 6, 1997·Neurochemistry International·J H LeeJ G Chung
Jun 1, 1991·Aging : Clinical and Experimental Research·G P TrentiniM Criscuolo
Feb 1, 1989·Biological Psychiatry·M SharmaN P Nair
Oct 6, 2005·Neurobiology of Aging·Robert E SchmidtLucie N Beaudet
Jan 1, 1991·Journal of the American Geriatrics Society·M A Brock
May 31, 1994·Annals of the New York Academy of Sciences·W Humbert, P Pevet
May 31, 1994·Annals of the New York Academy of Sciences·W Pierpaoli, V A Lesnikov
Jan 1, 1991·Annals of the New York Academy of Sciences·W PierpaoliW Regelson

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