Electrophysiological and pharmacological characterization of the direct perforant path input to hippocampal area CA3

Journal of Neurophysiology
J BerzhanskayaG Barrionuevo

Abstract

Monosynaptic perforant path responses evoked by subicular stimulation were recorded from CA3 pyramidal cells of rat hippocampal slices. These monosynaptic responses were isolated by using low intensities of stimulation and by placing a cut through the mossy fibers. Perforant path-evoked responses consisted of both excitatory and inhibitory components. Excitatory postsynaptic currents (EPSCs) were mediated by both alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidreceptors (AMPAR) and N-methyl--aspartate receptors (NMDAR). Inhibitory postsynaptic currents consisted of gamma-aminobutyric acid-A (GABAA-) and -B (GABAB)-receptor-mediated components. At membrane potentials more positive than -60 mV and at physiological [Ca2+]/[Mg2+] ratios, >30% of perforant path evoked EPSC was mediated by NMDARs. This value varied as a function of the membrane voltage and external [Mg2+]. Two types of responses were observed after low-intensity stimulation of the perforant path. The first type of response showed paired-pulse facilitation and was reduced by 2-amino-4-phosphonobutyric acid (AP4). The second type of response showed paired-pulse depression and was reduced by baclofen. Electrophysiological and pharmacological characteristics of t...Continue Reading

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Citations

Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·N N Urban, G Barrionuevo
Oct 20, 1999·Reviews in the Neurosciences·R BorisyukF Hoppensteadt
Apr 22, 2004·Nature Reviews. Neuroscience·Kazu NakazawaSusumu Tonegawa
Aug 22, 2007·Cellular and Molecular Neurobiology·Zhi HeLian-Jun Guo
Apr 5, 2008·The Journal of Physiology·Eduardo CalixtoGermán Barrionuevo
Sep 24, 1998·Journal of Neurophysiology·N N UrbanG Barrionuevo
Jul 2, 2002·Journal of Neurophysiology·David B T McMahon, German Barrionuevo
Jul 27, 2000·Annals of the New York Academy of Sciences·K J CanningL S Leung
Feb 5, 2002·Journal of Neurophysiology·Viet H DoBrian E Derrick
May 12, 2011·Molecular Neurobiology·Kathleen E CosgroveStephen D Meriney
Apr 26, 2012·The European Journal of Neuroscience·Satoko KoganemaruTatsuya Mima
Dec 18, 2013·Nature Neuroscience·Keigo KoharaSusumu Tonegawa
May 25, 2016·ELife·Shota ZarnadzeTengis Gloveli
Mar 19, 2016·Nature Communications·Noelia MadroñalAgnès Gruart
Jul 27, 2000·Annals of the New York Academy of Sciences·M E HasselmoA A Alonso
Sep 30, 2010·The Journal of Physiology·S AstoriG Köhr
Oct 12, 2010·Hippocampus·Licurgo de AlmeidaJohn E Lisman
Jun 28, 2000·Neuroscience·D A HenzeG Barrionuevo
Sep 4, 2001·Hippocampus·N N UrbanG Barrionuevo
Apr 21, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Etienne Coutureau, Georges Di Scala

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