Electrophysiological and theoretical analysis of melatonin in peripheral nerve crush injury

Journal of Neuroscience Methods
Serife Gokce ZencirciHalil Yaraneri

Abstract

Electrophysiological and theoretical studies have been performed to investigate peripheral nerve injuries and nerve regeneration. The aim of this work is to evaluate the effect of melatonin functionally and electrophysiologically on peripheral nerve crush injury. Adult male Wistar rats (n=32, 200+/-50 g) were randomly allocated into four groups. Sciatic crush was constituted on left sciatic nerves. Treatment groups received intraperitoneal melatonin at doses of 5 and 20mg/kg for 21 days. Functional nerve recovery was evaluated using sciatic functional index (SFI) every week during the experiment. In vivo electrophysiological measurements were performed at the end of the treatment. The electrophysiological data were also analyzed by wavelet analysis. Melatonin treatments increased the SFI values in the injured sciatic nerves. In vivo electrophysiological measurements showed that melatonin increased the conduction velocities and also decreased the latency values. The wavelet analysis showed that melatonin treatment reduced the densities of high frequency components of compound muscle action potential (CMAP). These results suggest that melatonin application is a promising strategy for the treatment of peripheral nerve crush injuri...Continue Reading

References

Aug 28, 2001·Brain Research. Brain Research Protocols·R Quian QuirogaM Schürmann
Oct 25, 2002·The Journal of Pharmacy and Pharmacology·Russel J ReiterSilvia Lopez-Burillo
Dec 17, 2003·Journal of Pineal Research·Carmen RodriguezRussel J Reiter
Feb 28, 2004·Journal of Neurotrauma·Antoni Valero-CabréWolfram F Neiss
Oct 16, 2004·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Martin K StilesPaul S Addison
Oct 12, 2005·Endocrine·Juan C MayoRussel J Reiter
Feb 1, 2006·Computers in Biology and Medicine·Sadik KaraSükrü Okkesim
May 9, 2006·Biochimica Et Biophysica Acta·Vladimir N AnisimovIrina A Vinogradova
Jan 16, 2007·Experimental Neurology·Chun-Jung ChenShan-Hui Hsu
Sep 18, 2007·Journal of the Peripheral Nervous System : JPNS·Godard C de RuiterAnthony J Windebank
Mar 8, 2008·Journal of Neuroscience Methods·Vanessa Vilela Monte-RasoGiuliano Barbieri
Oct 20, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jonathan J Halford

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Citations

Oct 12, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yasemin KayaFatoş Belgin Yıldırım
Nov 7, 2019·Hormone Molecular Biology and Clinical Investigation·Jia Xin MokSoi Moi Chye
Mar 12, 2020·Journal of Muscle Research and Cell Motility·Bide ChenTizhong Shan

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