Electrophysiological characteristics distinguish three classes of neuron in submucosal ganglia of the guinea-pig distal colon

Neuroscience
Alan E LomaxJ B Furness

Abstract

Intracellular recordings were made from neurons in the submucosal ganglia of the guinea-pig distal colon. The recording electrode contained the intracellular marker biocytin, which was injected into neurons so that their electrophysiological characteristics could be correlated with their shape. Correlations of electrophysiology and shape have not been reported previously for neurons in this region. Three types of neuron were identified on electrophysiological grounds. Neurons of the first type (S neurons) had tetrodotoxin-sensitive soma action potentials, and received fast and slow excitatory synaptic inputs. They had uniaxonal morphologies and may function as secretomotor or possibly vasomotor neurons. The second type (AH neurons) received only slow synaptic input, while the soma action potential had tetrodotoxin-sensitive and -insensitive components with a shoulder on the falling phase and a long-lasting afterhyperpolarisation of the membrane potential following a single action potential. Neurons of this type had multipolar morphologies and provided dense innervation of adjacent submucosal ganglia. These neurons are similar to the submucosal intrinsic primary afferent neurons of the guinea-pig small intestine. The final type ...Continue Reading

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Citations

Apr 6, 2004·Progress in Neurobiology·John B FurnessNadine Clerc
Feb 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ian M HonsKeith A Sharkey
Feb 2, 2013·Digestive Diseases and Sciences·Edward G HawkinsHamid I Akbarali
Dec 18, 2013·The Journal of Physiology·Jaime Pei Pei FoongJoel C Bornstein
May 13, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·John B FurnessVarsha V Lal
Feb 4, 2003·The Journal of Physiology·David R LindenGary M Mawe
Apr 1, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V WongS Vanner
Jun 21, 2005·European Journal of Pharmacology·Libor MrnkaJirí Pácha
Jul 17, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·X-C BianP P Bertrand
Sep 30, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan E LomaxKeith A Sharkey

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