Electrophysiological considerations regarding electrical stimulation of motor cortex and brain stem in humans

Neurosurgery
C CedzichS Schäfer

Abstract

To provide information about activation of descending motor pathways in humans, motor evoked potentials were obtained from 16 patients without any sensorimotor deficit, after both cortical and brain stem stimulation. Total anesthesia was achieved in all patients through intravenous administration. Short trains of one to five electrical pulses were delivered separately to the motor cortex and the brain stem. Compound muscle action potentials were recorded from the contralateral upper extremity. Threshold intensity, stimulus polarity, latencies, and effect of increased stimulus intensity on latencies were analyzed. The threshold intensity was significantly lower when stimulating the brain stem than when stimulating the cortex. A monophasic anodal stimulus was better for cortical stimulation than for brain stem stimulation. Conversely, a monophasic cathodal stimulus was more effective for brain stem stimulation. The rate of unsuccessful stimulations was higher with brain stem stimulation and with increased stimulation intensity. The variability of latencies was so high that a calculation of the conduction velocity of the motor pathways was not possible. The results indicate that cortical surface and brain stem stimulation act on d...Continue Reading

References

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Citations

Mar 3, 2020·Expert Review of Neurotherapeutics·Joshua K WongMichael S Okun
Jan 25, 2012·Neurosurgery·Kathleen SeidelAndreas Raabe
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