Electrophysiological determination of the site involved in generating abnormal muscle responses in hemifacial spasm

Muscle & Nerve
F TankéréJ C Willer

Abstract

In patients with hemifacial spasm (HFS), abnormal muscle responses due to abnormal cross-transmission are observed in facial muscles. However, the site in the facial nerve responsible for the cross-transmission remains a matter of controversy. We have developed a model in which by considering the electrophysiological parameters involved in producing the abnormal muscle response, we can determine the site of the abnormal cross-transmission within the facial nerve. This model was applied to HFS patients with three different etiologies: idiopathic, post-Bell's palsy, and post-XII-VII anastomosis. Our data show that: in idiopathic HFS, the cross-transmission may occur in the facial nerve at the level of the pontocerebellar angle; in post-Bell's palsy, it is inside the petrous bone; and in XII-VII anastomosis, it must be in the extracranial part of the facial nerve. The possible mechanisms for this cross talk are discussed in terms of ephaptic transmission or of a central hyperexcitability in the facial motor nucleus.

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Citations

Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·S MisawaT Hattori
Oct 30, 2009·The International Journal of Neuroscience·Tülay KurtCumhur Ertekin
Sep 22, 2009·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·Meral E KiziltanRahşan Sahin
Jan 23, 2013·Neurological Research·Xinyuan LiShiting Li
Dec 3, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marshall F WilkinsonAnthony M Kaufmann
May 14, 2016·Journal of Neurosurgery·Marshall F WilkinsonAnthony M Kaufmann
May 2, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Giovanni PavesiDomenico Mancia
Jul 13, 2002·Muscle & Nerve·Shinya YamashitaShigeki Kameyama
Mar 29, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Yasmine A AshramCharles D Yingling
Nov 25, 2005·Muscle & Nerve·Isabelle BernatFrédéric Tankéré
Apr 26, 2003·Arquivos de neuro-psiquiatria·Flavia Costa Nunes MachadoJoão Carlos Papaterra Limongi

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