Electrophysiological disturbances associated with acute myocardial infarction

European Heart Journal
D J SheridanW J Penny

Abstract

By the time most patients reach hospital with acute myocardial infarction the risk of developing ventricular fibrillation (VF) is receding and Q wave evolution is complete. While these changes are the culmination of a single irreversible ischaemic insult, this may follow several reversible episodes of ischaemia associated with marked ECG changes during the preceding hours or days and further ischaemic episodes may follow the development of Q waves. Cellular electrophysiological changes associated with experimental myocardial ischaemia in an isolated guinea pig preparation were a reduction in refractory period and action potential amplitude, Vmax and duration while conduction time and QRS width were prolonged. Spontaneous recovery in action potential amplitude and Vmax was observed after 12 min of ischaemia and depended on the presence of residual coronary flow. Electrophysiological recovery commenced rapidly on reperfusion but with further shortening of action potential duration. Reperfusion VF was most likely to occur when the associated ischaemic insult was 20-30 min in duration. Myocardial catecholamine depletion significantly reduced these arrhythmias and this antiarrhythmic action was associated with marked attenuation of ...Continue Reading

Citations

May 30, 2001·International Journal of Cardiology·R PudilS Behar
May 15, 2007·International Journal of Cardiology·Javier Jiménez-CandilCándido Martín-Luengo
Dec 23, 2009·Pacing and Clinical Electrophysiology : PACE·Javier Jiménez-CandilCándido Martín-Luengo
May 13, 2014·Journal of Cardiovascular Electrophysiology·Javier Jiménez-CandilPedro L Sánchez
Feb 28, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Lakshminarayan YerraScott D Solomon
May 24, 2005·The Korean Journal of Internal Medicine·Young Joon HongJung Chaee Kang
Apr 23, 2008·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·M Nadeem AttarRoger K Moore
Sep 19, 2019·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Javier Jiménez-CandilPedro L Sánchez
Jan 22, 2021·Journal of Cardiovascular Electrophysiology·Hiroshi HayashiTakashi Kurita

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