PMID: 6160339Jan 1, 1981Paper

Electrophysiological effects of antidepressants on mammalian hearts and crayfish giant axon

Journal of Cardiovascular Pharmacology
C M WangR A Maxwell

Abstract

Cardiotoxicity is known to occur in patients with or without preexisting cardiac diseases during treatments with the tricyclic antidepressants, amitriptyline and imipramine. The antiarrhythmic action of tricyclics was also demonstrated in clinical studies and in animal experiments. Bupropion, a novel antidepressant, is being studied in man and to date has been found to be effective and devoid of cardiovascular toxicity. This study was intended to show the direct effect of tricyclic antidepressants on excitable membrane and to compare their potential toxicity with bupropion in isolated tissues. In crayfish giant axon, all antidepressants exhibited local anesthetic-like action by reducing the action potential amplitude and maximal rate of upstroke (dv/dt). The tricyclics slowed spontaneous sinus discharges in rat atrium and prolonged the duration of evoked action potential in guinea pig atrium with a concomitant decrease in dv/dt. A quinidine-like action of the tricyclic agents is displayed in the termination of spontaneous depolarization and the suppression of dv/dt of evoked action potential in canine Purkinje fibers. The membrane depressant action of antidepressants resulted in the reduction of dv/dt and increased membrane ref...Continue Reading

Citations

Nov 13, 2015·Progress in Cardiovascular Diseases·Robyn M TeplyJames J DiNicolantonio
Sep 2, 2004·Pharmacotherapy·Cynthia A CarnesSubha V Raman
Jun 1, 2011·Fundamental & Clinical Pharmacology·Bertrand CaillierBenoit Drolet
Jan 1, 1987·Journal of Clinical Pharmacology·C M Lathers, L J Lipka
Sep 27, 2005·The Journal of Emergency Medicine·Steven C CurryWilliam Holubek
Jul 15, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Rebecca E Bruccoleri, Michele M Burns
Sep 21, 2016·Journal of Psychiatric Practice·Yuanjia ZhuXavier F Jimenez
Jun 27, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Nicholas A Buckley, Thomas A Faunce

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