Electrophysiological effects of imipramine in nontreated and in imipramine-pretreated rat atrial fibres

British Journal of Pharmacology
J Manzanares, J Tamargo

Abstract

1 The effect of imipramine (Imip) in concentrations between 10(-7)M and 5 X 10(-5)M has been studied on rat atrial transmembrane potentials. In another group of experiments the effect of Imip was studied in atrial fibres from rats pretreated for 24 days with twice daily intraperitoneal injections of Imip 7.5 mg/kg or saline. 2 In non-treated atria Imip depressed action potential amplitude and Vmax, reduced th e resting membrane potential and shifted the membrane responsiveness and recovery time curves downward and to the right. 3 Imip also prolonged the action potential duration and the effective refractory period, lengthening the effective refractory period relative to action potential duration. 4 Pretreatment with Imip decreased the resting membrane potential, amplitude and Vmax of the action potential and prolonged the effective refractory period. Further addition of Imip produced similar but more marked changes than in non-treated animals. 5 Imip suppressed the spontaneous atrial automaticity as well as the abnormal automaticity induced by BaCl2, aconitine, ouabain or isoprenaline. 6 The drug produced a negative inotropic effect and depressed the amplitude of the slow contractions elicited by isoprenaline in K-depolarized a...Continue Reading

References

Jul 1, 1978·Pharmacological Research Communications·F LeddaL Mantelli
Jan 27, 1977·The New England Journal of Medicine·J T BiggerA H Glassman
Jun 8, 1979·JAMA : the Journal of the American Medical Association·L E Hollister
Apr 15, 1979·European Journal of Pharmacology·J TamargoP Garcia de Jaloń
Feb 1, 1978·Hospital Practice·J T Biggs
Feb 1, 1977·Archives of General Psychiatry·A H GlassmanJ L Fleiss
May 1, 1973·Archives of General Psychiatry·A H Glassman, J M Perel
Jul 1, 1981·Circulation Research·B F Hoffman, M R Rosen
Jun 4, 1982·European Journal of Pharmacology·J TamargoM T Tejerina
Mar 7, 1980·European Journal of Pharmacology·J Tamargo
Sep 1, 1980·British Journal of Pharmacology·S Rodriguez, J Tamargo
Sep 1, 1958·British Journal of Pharmacology and Chemotherapy·E M VAUGHAN WILLIAMS
Oct 1, 1960·Archives of Surgery·E HOFFMAN

❮ Previous
Next ❯

Citations

Jan 22, 1985·European Journal of Pharmacology·G Isenberg, J Tamargo
Jun 18, 1991·European Journal of Pharmacology·F Pérez-VizcainoJ Tamargo
Jun 1, 1992·British Journal of Pharmacology·E DelpónJ Sánchez-Chapula
Jan 25, 2003·Journal of Clinical Psychopharmacology·Harry J WitchelDavid J Nutt
Feb 1, 1986·British Journal of Pharmacology·C DelgadoC Valenzuela

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.