PMID: 7426828Sep 1, 1980Paper

Electrophysiological effects of imipramine on bovine ventricular muscle and Purkinje fibres

British Journal of Pharmacology
S Rodriguez, J Tamargo

Abstract

1 The effect of imipramine in concentrations between 0.01 microM and 50 microM has been studied on bovine Purkinje fibres and ventricular muscle transmembrane potentials. 2 In electrically stimulated fibres, imipramine had no effect on the resting membrane potential, but decreased the action potential amplitude, overshoot and maximum rate of depolarization (Vmax). 3 In Purkinje fibres, imipramine also decreased the conduction velocity and shifted the membrane responsiveness and recovery time curves downward and to the right. 4 In both Purkinje fibres and ventricular muscle, imipramine decreased the amplitude of phase 2 and prolonged phase 3. In Purkinje fibres, imipramine did not alter the action potential duration (APD) but prolonged the effective refractory period (ERP). In ventricular muscle, at concentrations higher than 1 microM imipramine shortened both the APD and the ERP and made the ERP long as compared to APD. 5 Imipramine decreased the slope of phase 4 diastolic depolarization in spontaneously beating Purkinje fibres. 6 These properties of imipramine are quite similar to those of quinidine or procainamide (class 1 antiarrhythmics). The mechanisms responsible for the cardiac effect of imipramine are discussed.

References

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Citations

Aug 4, 2010·Cardiovascular Toxicology·Yoshitaka MitsumoriAtsushi Sugiyama
Nov 11, 1983·European Journal of Pharmacology·T TejerinaJ Tamargo
Jan 22, 1985·European Journal of Pharmacology·G Isenberg, J Tamargo
Jun 18, 1991·European Journal of Pharmacology·F Pérez-VizcainoJ Tamargo
Sep 19, 1996·European Journal of Pharmacology·A YoshidaC Shigemasa
Jan 1, 1989·General Pharmacology·M ManoachM Erez
Oct 23, 1997·Critical Care Clinics·P F Kolecki, S C Curry
Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader
Jun 1, 1992·British Journal of Pharmacology·E DelpónJ Sánchez-Chapula
Nov 2, 2011·The Veterinary Journal·R SacchettoF Mascarello
Jan 1, 1987·Journal of Clinical Pharmacology·C M Lathers, L J Lipka
Jan 1, 1989·Fundamental & Clinical Pharmacology·R H RouetB A Dupuis
Mar 18, 2011·Journal of Cellular Physiology·Michele CarboneHaining Yang
Mar 1, 1987·British Journal of Pharmacology·C DelgadoC Valenzuela
May 1, 1982·British Journal of Pharmacology·S BarrigonT Tejerina
Nov 1, 1985·British Journal of Pharmacology·J DiezC Valenzuela
May 1, 1983·British Journal of Pharmacology·J Manzanares, J Tamargo
Mar 1, 1986·Medical Toxicology·P R Pentel, N L Benowitz
Feb 1, 1986·British Journal of Pharmacology·C DelgadoC Valenzuela

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