Electrophysiological evaluation of the time-course of dopamine uptake inhibition induced by intravenous cocaine at a reinforcing dose

Neuroscience
Y Wakazono, Eugene A Kiyatkin

Abstract

Cocaine effectively inhibits dopamine (DA) uptake and this action appears to be the primary cause for increased DA transmission following systemic cocaine administration. Although this action had been reliably demonstrated in vivo with cocaine at high doses, data on the extent and the time-course of DA uptake inhibition induced by i.v. cocaine at low, reinforcing doses remain controversial. To clarify this issue, we examined how cocaine affects striatal neuronal responses to repeated iontophoretic DA applications in urethane-anesthetized rats. Because most striatal neurons during anesthesia have low, sporadic activity, DA tests were performed on cells tonically activated by continuous glutamate application. DA phasically decreased the activity of most dorsal and ventral striatal neurons; these responses in control conditions (i.v. saline) were current (dose) -dependent and remained highly stable following repeated DA applications at the same currents. DA also consistently decreased the activity of striatal neurons after i.v. cocaine (1 mg/kg); the magnitude of DA-induced inhibition slowly increased from approximately 5 min, became significantly larger from approximately 9 min, and peaked at 13-15 min after a single i.v. injecti...Continue Reading

References

Jan 1, 1989·Synapse·J S FowlerS J Gatley
Dec 1, 1989·Pharmacology, Biochemistry, and Behavior·H O Pettit, J B Justice
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Mar 16, 1987·Life Sciences·D K PittsJ Marwah
May 1, 1983·Pharmacology, Biochemistry, and Behavior·M W FischmanS Rajfer
Jun 1, 1995·Psychopharmacology·M StathisM J Kuhar
Jan 1, 1995·Brain Research. Brain Research Reviews·A Parent, L N Hazrati
Jan 15, 1994·The Journal of Physiology·M MichaelisW Jänig
Jun 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·D Servan-SchreiberM Mintun
Jan 9, 1999·European Journal of Pharmacology·J Poon, M van den Buuse
Nov 19, 2004·The European Journal of Neuroscience·Yolanda MateoSara R Jones
Nov 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Garret D StuberR Mark Wightman
May 14, 2005·Brain Research. Brain Research Reviews·Eugene A Kiyatkin
Jul 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael L A V HeienR Mark Wightman
Aug 24, 2005·The European Journal of Neuroscience·Eugene A Kiyatkin, P Leon Brown
Mar 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·B Jill VentonR Mark Wightman
Jul 21, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George V Rebec
Aug 26, 2006·The European Journal of Neuroscience·P Leon Brown, Eugene A Kiyatkin
Dec 16, 2006·Neuroscience Letters·Zhixia WangWilliam Woolverton
Apr 1, 1998·Addiction Biology·B AdinoffC H Kellner

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Citations

Sep 25, 2010·Psychopharmacology·Robert E HampsonSam A Deadwyler
Oct 17, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erik B OlesonEvgeny A Budygin

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